Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

122 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-11-30

Study Completion Date

2008-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate whether robust analgesic regime (protective analgesia) can improve postoperative pain experience for patients undergoing lower wisdom teeth extraction under day case general anaesthetic.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Ibuprofen, Paracetamol Versus Placebo on Pain During Local Anesthetic Injection (RCT)

NCT03184649

Analgesic Drugs Pain Relief

UNKNOWN PHASE1/PHASE2

Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction

NCT03893175

Impacted Third Molar Tooth Pain, Acute

COMPLETED PHASE1

Bupivacaine Supplementation For Postoperative Pain Control In Surgical Removal Of Mandibular Third Molars

NCT02353676

Anesthesia, Local

UNKNOWN NA

Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain

NCT01216163

Pain

COMPLETED PHASE3

Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction

NCT00050362

Pain Tooth Extraction

COMPLETED PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The aim of the study was to demonstrate and improve postoperative pain experience using protective analgesia for patients undergoing oral surgery under day case general anaesthesia.

The primary objective was to investigate the efficiency of protective analgesia using combined effects of sustained release ibuprofen and bupivacaine nerve block in attenuation of postoperative pain following impacted third molar surgery under day case general anaesthesia.

The secondary objective was to document the safety and tolerability profile of conventional release versus sustained released ibuprofen with bupivacaine block in subjects undergoing impacted third molar surgery under day case general anaesthesia.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Postoperative Pain Wisdom Tooth

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Conventional ibuprofen

Group Type ACTIVE_COMPARATOR

ibuprofen

Intervention Type DRUG

Single dose ibuprofen 2 x 200mg tablets 2 hours prior to surgery

Bupivacaine

Intervention Type DRUG

Up to 10ml of Bupivacaine 0.5% with 1:200,000 Adrenaline given prior to surgical incision as inferior alveolar nerve block and long buccal nerve infiltration.

Brufen retard

Group Type EXPERIMENTAL

Brufen retard

Intervention Type DRUG

Single dose 2 x 800mg tablets 2 hours prior to surgery

Bupivacaine

Intervention Type DRUG

Up to 10ml of Bupivacaine 0.5% with 1:200,000 Adrenaline given prior to surgical incision as inferior alveolar nerve block and long buccal nerve infiltration.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Brufen retard

Single dose 2 x 800mg tablets 2 hours prior to surgery

Intervention Type DRUG

ibuprofen

Single dose ibuprofen 2 x 200mg tablets 2 hours prior to surgery

Intervention Type DRUG

Bupivacaine

Up to 10ml of Bupivacaine 0.5% with 1:200,000 Adrenaline given prior to surgical incision as inferior alveolar nerve block and long buccal nerve infiltration.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

sustained release ibuprofen modified release ibuprofen Brufen neurofen conventional release ibuprofen Marcain 0.5% with 1 in 200,000 epinephrine

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* healthy male and female patients aged 18 years and over
* patients requiring removal of one or more third molars, with at lease one completely or partially impacted in the mandible needing bone removal