Comparative Experimental Study Between Bupivacaine and Ropivacaine Regarding Efficacy in Third Molar Removal Surgery Under General Anesthesia
NCT ID: NCT07108465
Last Updated: 2026-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
EARLY_PHASE1
15 participants
INTERVENTIONAL
2025-07-01
2025-12-31
Brief Summary
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Researchers will compare bupivacaine and ropivacaine in a split-mouth study to determine if one drug is more effective in third molar extraction surgery under general anesthesia (better hemostasis, less postoperative pain, and fewer changes in vital signs). Participants will undergo a single surgical procedure and complete the Visual Analog Scale to record postoperative pain
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
SUPPORTIVE_CARE
NONE
Study Groups
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Group A - Bupivacaine
use of bupivacaine 0,5% + epinephrine 0,2mL in third molar surgery in general anesthesia
Bupivacaine 0,5%
Injection of bupivacaine 0,5% in group A
Group B - Ropivacaine
use of ropivacaine 0,75% + epinephrine 0,2mL in third molar surgery in general anesthesia
Ropivacaine 0,75%
Injection of ropivacaine 0,75% in group B
Interventions
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Bupivacaine 0,5%
Injection of bupivacaine 0,5% in group A
Ropivacaine 0,75%
Injection of ropivacaine 0,75% in group B
Eligibility Criteria
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Inclusion Criteria
* Patients ASA Physical Status Classification I and II
* Patients with impacted or semi-impacted lower third molars with similar positioning on both sides according to the Pell and Gregory classification
Exclusion Criteria
* Patients where more procedures are required in the same surgical session
18 Years
60 Years
ALL
Yes
Sponsors
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Henrique Tedesco
OTHER
Responsible Party
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Henrique Tedesco
Principal Investigator
Locations
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Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Countries
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Central Contacts
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Facility Contacts
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References
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Kalath RN, Kulal R, Gopinath S. Comparison of clinical efficacy of ropivacaine and lignocaine with adrenaline for implant surgery anesthesia: a split-mouth randomized controlled clinical trial. J Dent Anesth Pain Med. 2021 Aug;21(4):337-344. doi: 10.17245/jdapm.2021.21.4.337. Epub 2021 Jul 30.
Provided Documents
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Document Type: Study Protocol and Informed Consent Form
Other Identifiers
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89726325.2.0000.5327
Identifier Type: -
Identifier Source: org_study_id
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