Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2021-12-10
2022-02-02
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Modified dosage
Ibuprofen pill at morning and afternoon; Placebo at night
Ibuprofen 400 mg
morning and afternoon
Normal dosage
Ibuprofen three times a day: morning, afternoon and night
Ibuprofen 400 mg
morning, afternoon and night
Interventions
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Ibuprofen 400 mg
morning and afternoon
Ibuprofen 400 mg
morning, afternoon and night
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Bilateral retained lower third molar
Exclusion Criteria
* Contraindication for surgical removal of third molar
18 Years
35 Years
ALL
Yes
Sponsors
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McGill University
OTHER
Universidad Complutense de Madrid
OTHER
Responsible Party
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Jesús Torres García Denche
Associate professor
Locations
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Fabian Perez Gonzalez
Madrid, , Spain
Countries
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References
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Gutierrez-Corrales A, Campano-Cuevas E, Castillo-Dali G, Serrera-Figallo MA, Torres-Lagares D, Gutierrez-Perez JL. Relationship between salivary biomarkers and postoperative swelling after the extraction of impacted lower third molars. Int J Oral Maxillofac Surg. 2017 Feb;46(2):243-249. doi: 10.1016/j.ijom.2016.10.005. Epub 2016 Nov 3.
Albuquerque AFM, Fonteles CSR, do Val DR, Chaves HV, Bezerra MM, Pereira KMA, de Barros Silva PG, de Lima BB, Soares ECS, Ribeiro TR, Costa FWG. Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-alpha and IL-1beta in third molar surgery: a triple-blind, randomized, placebo-controlled study. Int J Oral Maxillofac Surg. 2017 Dec;46(12):1615-1625. doi: 10.1016/j.ijom.2017.05.007. Epub 2017 Jun 10.
Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A, Maier B. A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21407-12. doi: 10.1073/pnas.0906361106. Epub 2009 Dec 1.
Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA. Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. doi: 10.1073/pnas.1501327112. Epub 2015 May 20.
Other Identifiers
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2019-000736-25
Identifier Type: -
Identifier Source: org_study_id
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