Impact of Preemptive Intravenous Ibuprofen on Intraoperative Analgesia in Third Molar Teeth

NCT ID: NCT03170726

Last Updated: 2017-05-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-15

Study Completion Date

2017-11-15

Brief Summary

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This study was planned to evaluate the analgesic efficacy of preemptive intravenous (iv) ibuprofen on pain occurring during and after the mandibular third molar surgeon

Detailed Description

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Conditions

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Preemptive Intravenous Ibuprofen Intraoperative Analgesia

Keywords

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Preemptive intravenous ibuprofen Intraoperative analgesia Third molar tooth surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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arveles

Ibuprofen 800 mg in normal saline 150 cc and dexketoprofen (50 mg) before operation will be given in 30 minutes

Group Type ACTIVE_COMPARATOR

arveles

Intervention Type DRUG

Intraoperative and postoperative pain values between these three groups will be compared.

intrafen 800 mg

Intervention Type DRUG

ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

plasebos

Intervention Type OTHER

normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

intrafen

intrafen 800 mg in normal saline 150 cc before operation will be given in 30 minutes

Group Type ACTIVE_COMPARATOR

arveles

Intervention Type DRUG

Intraoperative and postoperative pain values between these three groups will be compared.

intrafen 800 mg

Intervention Type DRUG

ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

plasebos

Intervention Type OTHER

normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

plasebos

150 cc normal saline will be given in 30 minutes during preoperative period

Group Type PLACEBO_COMPARATOR

arveles

Intervention Type DRUG

Intraoperative and postoperative pain values between these three groups will be compared.

intrafen 800 mg

Intervention Type DRUG

ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

plasebos

Intervention Type OTHER

normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

Interventions

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arveles

Intraoperative and postoperative pain values between these three groups will be compared.

Intervention Type DRUG

intrafen 800 mg

ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

Intervention Type DRUG

plasebos

normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

Intervention Type OTHER

Other Intervention Names

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dexketoprofen ibuprofen i.v.

Eligibility Criteria

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Inclusion Criteria

* Patients who are to be elected third molar tooth extraction
* Patients between the ages of 20-35
* Patients who are symptomatic
* Third molar tooth angular or horizontal settled patients

Exclusion Criteria

* Patients who refuse to participate in the study
* Patients under 20 years old, over 35 years old
* Patients who are allergic to known non-steroidal anti-inflammatory drugs
* Pregnant patients
* Patients with severe liver failure,
* patients with severe renal insufficiency
Minimum Eligible Age

20 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Erzincan University

OTHER

Sponsor Role lead

Responsible Party

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ILKE KUPELI

assist. prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ilke kupeli

Role: PRINCIPAL_INVESTIGATOR

Erzincan University

Locations

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Erzincan University

Erzincan, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Jerjes W, El-Maaytah M, Swinson B, Banu B, Upile T, D'Sa S, Al-Khawalde M, Chaib B, Hopper C. Experience versus complication rate in third molar surgery. Head Face Med. 2006 May 25;2:14. doi: 10.1186/1746-160X-2-14.

Reference Type BACKGROUND
PMID: 16725024 (View on PubMed)

Oscier CD, Milner QJ. Peri-operative use of paracetamol. Anaesthesia. 2009 Jan;64(1):65-72. doi: 10.1111/j.1365-2044.2008.05674.x.

Reference Type BACKGROUND
PMID: 19087009 (View on PubMed)

Hariharan S, Moseley H, Kumar A, Raju S. The effect of preemptive analgesia in postoperative pain relief--a prospective double-blind randomized study. Pain Med. 2009 Jan;10(1):49-53. doi: 10.1111/j.1526-4637.2008.00547.x.

Reference Type BACKGROUND
PMID: 19222770 (View on PubMed)

Trampitsch E, Pipam W, Moertl M, Sadjak A, Dorn C, Sittl R, Likar R. [Preemptive randomized, double-blind study with lornoxicam in gynecological surgery]. Schmerz. 2003 Jan;17(1):4-10. doi: 10.1007/s00482-001-0129-7. German.

Reference Type RESULT
PMID: 12579384 (View on PubMed)

Buvanendran A, Kroin JS. Multimodal analgesia for controlling acute postoperative pain. Curr Opin Anaesthesiol. 2009 Oct;22(5):588-93. doi: 10.1097/ACO.0b013e328330373a.

Reference Type RESULT
PMID: 19606021 (View on PubMed)

Other Identifiers

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ERZINCAN UNIVERSITY 9

Identifier Type: -

Identifier Source: org_study_id