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A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults

NCT ID: NCT06269406

Last Updated: 2025-06-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

264 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-28

Study Completion Date

2025-09-28

Brief Summary

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Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.

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Detailed Description

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Conditions

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Dental Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Intervention Group ibuprofen 400 and Curcumin

Group Type EXPERIMENTAL

ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg

Intervention Type DIETARY_SUPPLEMENT

The combination of ibuprofen 400 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure

Intervention Group ibuprofen 200 and Curcumin

Group Type EXPERIMENTAL

ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg

Intervention Type DIETARY_SUPPLEMENT

The combination of ibuprofen 200 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure

Intervention Group ibuprofen 400 and placebo

Group Type PLACEBO_COMPARATOR

The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure

Intervention Type OTHER

The combination of ibuprofen 400 mg and placebo 100 mg in patients after 2-4 molars procedure

Interventions

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ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg

The combination of ibuprofen 400 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure

Intervention Type DIETARY_SUPPLEMENT

ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg

The combination of ibuprofen 200 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure

Intervention Type DIETARY_SUPPLEMENT

The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure

The combination of ibuprofen 400 mg and placebo 100 mg in patients after 2-4 molars procedure

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Removal of 2 to 4 impacted third molars

Exclusion Criteria

* Pregnancy or breastfeeding
* Ibuprofen contraindications.
* Allergy to any of the intervention components.
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NMSI DENTMASTER

OTHER

Sponsor Role collaborator

S.LAB (SOLOWAYS)

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Nmsi Dentmaster

Novosibirsk, Novosibirsk Oblast, Russia

Site Status

Countries

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Russia

Facility Contacts

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Gatilova A Tatyana, MD

Role: primary

9529399919 ext. +7

Other Identifiers

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SW008

Identifier Type: -

Identifier Source: org_study_id

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