Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2008-05-31
2010-12-31
Brief Summary
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The investigators aim is to investigate the long-term effects of intake of soft drinks, milk and water. The study is a parallel, intervention trial with 80 overweight, healthy volunteers. They will be randomly selected to drink one liter a day of one of the four drinks for six months. The objectives are changes in numerous circulating metabolic risk factors, changes in body weight, anthropometric data and fat distribution (measured by DEXA, MRI and MR-spectroscopy).
The investigators expect to clarify the mechanisms linking drinking habits to obesity development and provide scientifically based nutritional guidelines.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Sugar-sweetened soft drink
54g sugar/L, 180kJ/100mL
Sugar-sweetened soft drink
One litre a day for six months.
Aspartame-sweetened soft drink
1.5kJ/100mL
Aspartame-sweetened soft drink
One litre a day for six months.
Semi-skimmed milk
202kJ/100mL
Semi-skimmed milk
One litre a day for six months
Water
0kJ/100mL
Water
One litre a day for six months.
Interventions
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Sugar-sweetened soft drink
One litre a day for six months.
Aspartame-sweetened soft drink
One litre a day for six months.
Semi-skimmed milk
One litre a day for six months
Water
One litre a day for six months.
Eligibility Criteria
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Inclusion Criteria
* BMI between 28-36 kg/m2;
* Weight stabile 3 months prior to the study inclusion;
* Less than 10 hours of weekly exercise
Exclusion Criteria
* Allergic to phenylalanine or milk
* Smoking
* Pregnancy or breast-feeding
20 Years
50 Years
ALL
Yes
Sponsors
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LG Life Sciences
INDUSTRY
Aarhus University Hospital
OTHER
Responsible Party
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Maria Maersk Nielsen
MD, PHD
Principal Investigators
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Bjørn Richelsen, Professor
Role: STUDY_CHAIR
Department of Internal Medicine/Endocrinology C, Aarhus University Hospital
Locations
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Department of Internal Medicine/Endocrinology C, Aarhus University Hospital
Aarhus, , Denmark
Countries
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References
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Bajahzer MF, Bruun JM, Rosqvist F, Marklund M, Richelsen B, Riserus U. Effects of sugar-sweetened soda on plasma saturated and monounsaturated fatty acids in individuals with obesity: A randomized study. Front Nutr. 2022 Aug 31;9:936828. doi: 10.3389/fnut.2022.936828. eCollection 2022.
Bruun JM, Maersk M, Belza A, Astrup A, Richelsen B. Consumption of sucrose-sweetened soft drinks increases plasma levels of uric acid in overweight and obese subjects: a 6-month randomised controlled trial. Eur J Clin Nutr. 2015 Aug;69(8):949-53. doi: 10.1038/ejcn.2015.95. Epub 2015 Jun 17.
Maersk M, Belza A, Stodkilde-Jorgensen H, Ringgaard S, Chabanova E, Thomsen H, Pedersen SB, Astrup A, Richelsen B. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. 2012 Feb;95(2):283-9. doi: 10.3945/ajcn.111.022533. Epub 2011 Dec 28.
Other Identifiers
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20070134B
Identifier Type: -
Identifier Source: org_study_id
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