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Biomarkers of Aneurysm Wall Strength

NCT ID: NCT00740740

Last Updated: 2008-08-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-06-30

Study Completion Date

2010-01-31

Brief Summary

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The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.

Detailed Description

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Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength

Conditions

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Abdominal Aortic Aneurysm

Keywords

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Aneurysm Rupture

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Patients scheduled for elective conventional aneurysm repair

No interventions assigned to this group

2

Patients scheduled for emergent conventional aneurysm repair

No interventions assigned to this group

3

Patients scheduled for aortic bypass surgery

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patient scheduled for transabdominal aortic surgery

Exclusion Criteria

* Patient characteristics and aneurysm anatomy suitable for endovascular repair
* Previous aortic surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Radboud University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Radboud University Nijmegen Medical Centre

Principal Investigators

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Jan Blankensteijn

Role: PRINCIPAL_INVESTIGATOR

Radboud University Medical Center

Locations

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Alysis Zorggroep, Rijnstate Hospital

Arnhem, Gelderland, Netherlands

Site Status RECRUITING

Radboud University Nijmegen Medical Center

Nijmegen, Gelderland, Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Maarten Truijers, MD

Role: CONTACT

Phone: 0031-24-3615333

Email: [email protected]

Facility Contacts

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Steven Sterkenburg, MD

Role: primary

Maarten Truijers, MD

Role: primary

Other Identifiers

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Wallstrength_01

Identifier Type: -

Identifier Source: org_study_id