Non Invasive Imaging of Abdominal Aorta Aneurysm Hemodynamics and Wall Structure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-03-31

Study Completion Date

2012-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The development of the abdominal aorta aneurysm is multifactorial. Through use of magnetic resonance imaging without contrast, this study will look closely at flow, the stresses hereby induced, as well as signs of inflammation in the vessel wall.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Predicting Rupture of AAA by Anatomic and Hemodynamic Markers

NCT02463760

Aortic Aneurysm, Abdominal

COMPLETED

Magnetic Resonance Imaging of Aortic Aneurysm Instability

NCT00794092

Aortic Aneurysm

COMPLETED PHASE2/PHASE3

Ultrasound Velocimetry in the Abdominal Aorta Before and After Endovascular Aneurysm Repair

NCT05148988

Abdominal Aortic Aneurysm

COMPLETED

Development of Novel Imaging Markers Predicting the Progression of Abdominal Aortic Aneurysm Using 3D Computed Tomography

NCT04333641

Abdominal Aortic Aneurysm (AAA)

COMPLETED

Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms

NCT03142074

Thoracic Aortic Aneurysms

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The etiology of the abdominal aorta aneurysm is complex and multi-factorial. Biomechanic and hemodynamic stress contributes to aneurysmal growth, and the relevance of inflammation is gaining in terms of pathological influence. The technical advances of imaging now enable one to utilize magnetic resonance in reconstructing aortal blood flow. Newer post-imaging software then enables one to perform complex data analysis, wherein shear and wall-stress can be calculated. The goal of this study is to analyze the aneurysms of twenty patients. Values will be obtained for shear and wall stress. Additionally, the utilization of short tau wave inversion recovery (STIR) sequences will be performed to evaluate the presence or absence of acute edema and inflammation of the region. It should also be noted that particular attention will be placed on the so-called "neck" of the aneurysm, where the aneurysm typically tapers into what is often regarded as normal aortic tissue. This region is important for both the placement of a surgical bypass prosthesis or a deployed stent graft.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aortic Aneurysm, Abdominal

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Infrarenal abdominal aorta aneurysm (AAA)

Exclusion Criteria

* Lack of signed, informed consent
* Pacemaker or other implanted metal prostheses
* Claustrophobia
* Dementia
* Diabetes Mellitus
* Thoracoabdominal aorta aneurysm, per Crawford/Safi criteria
* Ehlers-Danlos, Marfans, or other diagnosed connective tissue disease

Minimum Eligible Age

20 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes