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Calcium and Lipid Metabolism

NCT ID: NCT00686192

Last Updated: 2008-07-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-09-30

Study Completion Date

2002-07-31

Brief Summary

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We hope to determine if supplementing the diet of women who habitually consume low levels of calcium, with 1500 mg of calcium a day for three months will increase fat oxidation and decrease fat storage. We will also measure concentrations of lipids, glucose, hormones and enzymes associated with fat and carbohydrate metabolism to determine alterations and mechanism of the metabolic changes.

Detailed Description

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The incidence of obesity has rapidly increased in recent years and reached epidemic proportions in the United States. Recent epidemiological data has shown an inverse relationship between calcium intake and body fat and emerging research suggests that inadequate dietary calcium consumption may increase obesity. Studies in mice have shown that an increase in dietary calcium consumption creates a shift in the utilization of energy stores from carbohydrates to fat and a shift in the partitioning of energy from storage (as fat) to expenditure (as heat).

We will give 1500 mg of calcium a day for three months to women who habitually consume low levels of dietary calcium. The following measurements will be made before and after calcium supplementation: body fat by DEXA, lipolysis by infusion of stable isotopes of 1,1,2,3,3-\[2H5\] glycerol , hepatic glucose production by infusion of stable isotopes of 6,6-\[2H2\] glucose, lipogenesis by measurement of fatty acid synthase activity (14C radiochemical assay) , mRNA expression ( Real Time Polymerase Chain Reaction) and protein content (ELISA), indirect calorimetry measurement of non-protein respiratory quotient (NPRQ), energy expenditure, fat and carbohydrate oxidation. Serum calcium, glucose, cholesterol, triglycerides, LDL, HDL, parathyroid hormone, leptin, free fatty acids, adiponectin, 1,25(OH)2D, 25(OH)D and urinary calcium excretion will also be measured.

Conditions

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Obesity

Keywords

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Obesity Calcium carbonate Dietary Supplements Lipolysis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Calcium Carbonate

1500 mg per day

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* BMI between 25 and 30 kg/m2
* Taking oral contraceptives
* Having regular menses

Exclusion Criteria

* Pregnant
* History of metabolic bone, renal or thyroid disease,
* History of diabetes mellitus, or gestational diabetes mellitus
* Cigarette smoking
* Self-administration of calcium supplements
* Regular aerobic activity, i.e. jogging \> 1 mile/day
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, Davis

OTHER

Sponsor Role collaborator

San Francisco General Hospital

OTHER

Sponsor Role collaborator

USDA, Western Human Nutrition Research Center

FED

Sponsor Role lead

Responsible Party

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Children's Hospital Oakland Research Institute

Principal Investigators

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Janet C King, PhD

Role: PRINCIPAL_INVESTIGATOR

UCSF Benioff Children's Hospital Oakland

Locations

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San Francisco General Hospital

San Francisco, California, United States

Site Status

Countries

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United States

Related Links

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http://www.ars.usda.gov/main/site_main.htm?modecode=53062500

USDA Western Human Nutrition Research Center

Other Identifiers

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WHNRC001

Identifier Type: -

Identifier Source: org_study_id