Calcium Retention as Influenced by Dietary Components That Induce an Acid Load

NCT ID: NCT00620763

Last Updated: 2018-07-02

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Study Completion Date

2008-05-31

Brief Summary

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The impact of protein sources such as beef as part of Western diet on calcium retention remains controversial. We propose to test the hypothesis that the positive effect of high protein intake (especially from meat protein) can offset the negative effect of protein-induced net acid load on bone metabolism and the retention of body calcium. Healthy postmenopausal women recruited from the community will consume two diets differing in meat protein and acid load for 7 weeks. Calcium retention from diets will be determined using a highly sensitive measurement of whole body retention of a calcium isotope added to the diet.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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A

Dietary Intervention: High meat and high acid load diet followed by low meat and low acid load diet

Group Type EXPERIMENTAL

High Meat - High Potential Renal Acid Load (PRAL) diet

Intervention Type OTHER

Menu high in meat protein

Low Protein - Low Potential Renal Acid Load (PRAL) diet

Intervention Type OTHER

Menu low in meat protein

B

Dietary Intervention: Low meat and low acid load diet followed by high meat and high acid load diet

Group Type EXPERIMENTAL

High Meat - High Potential Renal Acid Load (PRAL) diet

Intervention Type OTHER

Menu high in meat protein

Low Protein - Low Potential Renal Acid Load (PRAL) diet

Intervention Type OTHER

Menu low in meat protein

Interventions

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High Meat - High Potential Renal Acid Load (PRAL) diet

Menu high in meat protein

Intervention Type OTHER

Low Protein - Low Potential Renal Acid Load (PRAL) diet

Menu low in meat protein

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Average body mass index
* Normal blood work
* Normal bone density

Exclusion Criteria

* Chronic disorder
* Non-traumatic bone fractures
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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USDA Grand Forks Human Nutrition Research Center

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jay Cao, PhD

Role: PRINCIPAL_INVESTIGATOR

USDA Grand Forks Human Nutrition Research Center

Locations

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United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, United States

Site Status

Countries

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United States

References

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Roughead ZK, Johnson LK, Lykken GI, Hunt JR. Controlled high meat diets do not affect calcium retention or indices of bone status in healthy postmenopausal women. J Nutr. 2003 Apr;133(4):1020-6. doi: 10.1093/jn/133.4.1020.

Reference Type BACKGROUND
PMID: 12672913 (View on PubMed)

Cao JJ, Johnson LK, Hunt JR. A diet high in meat protein and potential renal acid load increases fractional calcium absorption and urinary calcium excretion without affecting markers of bone resorption or formation in postmenopausal women. J Nutr. 2011 Mar;141(3):391-7. doi: 10.3945/jn.110.129361. Epub 2011 Jan 19.

Reference Type DERIVED
PMID: 21248199 (View on PubMed)

Other Identifiers

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IRB-2000707-013

Identifier Type: -

Identifier Source: secondary_id

GFHNRC087

Identifier Type: -

Identifier Source: org_study_id

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