Combination Plant-Based Protein and Marine-Based Multi-Mineral Supplement and Bone Remodeling in Young Adults

NCT ID: NCT05533502

Last Updated: 2023-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-01

Study Completion Date

2022-10-31

Brief Summary

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Nutrient intake of calcium and protein are known to function as regulators of bone remodeling. Specifically, a balanced rate of bone resorption and bone formation (i.e. bone remodeling process) is required to maintain bone health. However, a high remodeling rate, or an imbalance between formation and resorption, as well as suboptimal nutrient intake are known to contribute to fracture risk and bone dysfunction.

Gut-derived hormones represent an important link between nutrient intake and bone remodeling (i.e. gut-bone axis). A sustainable nutritional intervention that positively modulates the postprandial responses of gut-derived hormones and the linked bone remodeling processes is an attractive option for the optimization of bone health in young adults.

The proposed nutrient intervention seeks to explore the bioefficacy of a combination plant-based protein and marine-based multi-mineral supplement following oral ingestion in young, healthy men and women. A postprandial time-course study will be undertaken to examine the acute effects and/or associations between different gut-derived hormones and biomarkers of bone metabolism.

Detailed Description

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A block-randomized, within-subject, two-day, crossover design examining acute (0-4 hour) postprandial changes in different gut-derived hormone concentrations and biomarkers of bone metabolism in 12 healthy, young adults following ingestion of a combination plant-based protein and marine-based multi-mineral supplement or control.

Each participant will consume (in a random manner) either one of two investigational products (i.e., combined nutritional supplement or control). The combined nutritional supplement will consist of: 0.3 g/kg body mass of ATURA Fava-Bean Protein and 800mg of Aquamin F (a highly bioactive source of minerals rich in calcium) dissolved in 500ml water volume. The control product will consist of 500ml water volume without the protein and multi-mineral nutritional composition.

Conditions

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Bone Resorption Bone and Bones

Keywords

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nutrition plant marine protein bone skeletal health dietary supplements sustainable

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

A block-randomized, within-subject, two-day, crossover design examining acute (0-4 h) postprandial changes in different gut hormone concentrations and bone remodeling biomarkers in 12 healthy, young adults following ingestion of a combination plant-based protein and marine-based multi-mineral supplement or control.
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Investigators
Single Blind Study (Investigator only)

Study Groups

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Dietary Supplement: Combined Plant-Based Protein and Marine-Based Multi-Mineral Supplement

Fava-Bean Protein Concentrate and Aquamin F

Group Type ACTIVE_COMPARATOR

Combined Plant-Based Protein and Marine-Based Multi-Mineral Supplement

Intervention Type DIETARY_SUPPLEMENT

Ingestion of the Test Product at 07.00am - Fava-bean protein concentrate dosed at 0.33 g/kg body mass and Aquamin F dosed at 800mg in 500 ml water volume. Supplied by Marigot Limited, Strand Farm Currabinny, Co. Cork, Ireland

Placebo Control

Placebo Control

Group Type PLACEBO_COMPARATOR

Placebo Control

Intervention Type DIETARY_SUPPLEMENT

Ingestion of the Control Product at 07.00am - 500ml water volume.

Interventions

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Combined Plant-Based Protein and Marine-Based Multi-Mineral Supplement

Ingestion of the Test Product at 07.00am - Fava-bean protein concentrate dosed at 0.33 g/kg body mass and Aquamin F dosed at 800mg in 500 ml water volume. Supplied by Marigot Limited, Strand Farm Currabinny, Co. Cork, Ireland

Intervention Type DIETARY_SUPPLEMENT

Placebo Control

Ingestion of the Control Product at 07.00am - 500ml water volume.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Men and women aged 18 to 35 years.
* Recreationally active (150-300 min/week of moderate physical activity).
* Healthy (i.e.,not presenting with injury, illness, medication, history of chronic disease, or known allergies/intolerance (e.g. favism) to the ingredients contained in either formulation.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Marigot Ltd.

INDUSTRY

Sponsor Role collaborator

Enterprise Ireland

OTHER_GOV

Sponsor Role collaborator

University of Limerick

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Philip M Jakeman, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Limerick

Locations

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Faculty of Education & Health Sciences, University of Limerick,

Limerick, , Ireland

Site Status

Countries

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Ireland

Related Links

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Other Identifiers

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2022_03_06_EHS

Identifier Type: -

Identifier Source: org_study_id