Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension
NCT ID: NCT00575692
Last Updated: 2014-05-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
240 participants
OBSERVATIONAL
2006-12-31
2013-12-31
Brief Summary
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All patients who showed elevated pulmonary pressure in the right heart catheter investigation are assigned to MRI. Parameters derived from MRI are included in the clinical and therapeutic decisions. Well established as well as new MRI parameters are evaluated and compared to the results of right heart catheter. Further age-matched controls without known cardiac or pulmonary disease are investigated by native MRI.
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Detailed Description
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* Planning of cardiac views: Planning of 2-chamber view, short axes view and 4-chamber view.
* Morphological overview: Transversal and coronal Haste images
* Left and right heart functional and valve evaluation: Cine 2-chamber imaging, Multi-slice cine 4-chamber imaging, Cine Left and Right ventricular outflow tract imaging and Multi-slice cine short axes imaging covering the left and right ventricle for evaluation of EDV, ESV, SV, EF, CO and muscle mass.
* Phase Contrast Imaging: Flow measurements in the aorta, the pulmonary artery and the heart.
* Perfusion measurement.
* Late enhancement measurement: Multi-slice short axes view, multi-slice 2-chamber view and multi-slice 4-chamber view.
Conditions
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Study Groups
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PulmoHypertension
Patients with suspected, latent or manifest pulmonary hypertension
No interventions assigned to this group
Controls
Controls without history of cardiac or pulmonary diseases
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients with suspected PH
* Patients with latent PH
* Patients with manifest PH
18 Years
ALL
Yes
Sponsors
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Medical University of Graz
OTHER
Responsible Party
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Olschewski, Horst, Prof. MD
Univ.-Prof. Dr.
Principal Investigators
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Gabor Kovacs, MD
Role: PRINCIPAL_INVESTIGATOR
Medical Unitersity Graz, University Clinic of Internal Medicine, Department of Pulmonology
Ursula Reiter, PhD
Role: PRINCIPAL_INVESTIGATOR
Medical Unitersity Graz, University Clinic of Radiology, Department of General Radiological Diagnostics
Gert Reiter, PhD
Role: PRINCIPAL_INVESTIGATOR
Siemens Medical Austria
HOrst Olschewski, M.D.
Role: PRINCIPAL_INVESTIGATOR
Medical University of Graz
Locations
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Medical Unitersity Graz, University Clinic of Internal Medicine, Department of Pulmonology
Graz, Stmk., Austria
Countries
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References
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Reiter G, Reiter U, Kovacs G, Kainz B, Schmidt K, Maier R, Olschewski H, Rienmueller R. Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure. Circ Cardiovasc Imaging. 2008 Jul;1(1):23-30. doi: 10.1161/CIRCIMAGING.108.780247.
Reiter G, Kovacs G, Reiter C, Schmidt A, Fuchsjager M, Olschewski H, Reiter U. Left atrial acceleration factor as a magnetic resonance 4D flow measure of mean pulmonary artery wedge pressure in pulmonary hypertension. Front Cardiovasc Med. 2022 Aug 3;9:972142. doi: 10.3389/fcvm.2022.972142. eCollection 2022.
Reiter U, Kovacs G, Reiter C, Krauter C, Nizhnikava V, Fuchsjager M, Olschewski H, Reiter G. MR 4D flow-based mean pulmonary arterial pressure tracking in pulmonary hypertension. Eur Radiol. 2021 Apr;31(4):1883-1893. doi: 10.1007/s00330-020-07287-6. Epub 2020 Sep 24.
Reiter G, Reiter U, Kovacs G, Olschewski H, Fuchsjager M. Blood flow vortices along the main pulmonary artery measured with MR imaging for diagnosis of pulmonary hypertension. Radiology. 2015 Apr;275(1):71-9. doi: 10.1148/radiol.14140849. Epub 2014 Nov 5.
Other Identifiers
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PH-06-CMR-01
Identifier Type: -
Identifier Source: org_study_id
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