Optimization of Cardiac-MR Protocols

NCT ID: NCT00557869

Last Updated: 2011-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

122 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-10-31

Study Completion Date

2011-09-30

Brief Summary

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The aim of the present study is the optimization of various magnetic resonance (MR) investigation protocols of the heart and the lung without contrast agent application as well as the generation of normal values from cardiac MR images. One of the main problems in cardiac MR investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations with special emphasis on phase-contrast imaging and other cine-techniques.

Detailed Description

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Time optimized and well organized MR protocols for the cardiac and lung investigations are evaluated on normal subjects with special respect to following topics:

1. Localization: Definition of standardized anatomic imaging planes with special respect to the right ventricle.
2. Morphological imaging: Optimization of spin-echo and gradient-echo sequences for various heart frequencies and breath-hold abilities. Investigation of the effect of various preparation pulses. Optimization of the signal-to-noise ratio for morphological cardiac imaging. Evaluation and optimization of various breathing and breath-hold (with and without navigator) ECG and pulse triggered sequences.
3. Cardiac and lung function: Optimization of gradient-echo sequences for various heart frequencies and breath-hold abilities. Evaluation of pulse-triggered function analysis and optimization of free breathing protocols. Optimization of tagging techniques. Evaluation of the pulsatile flow in lung vessels. Acquisition of age depended normal data of cardiac and lung function.
4. Coronary imaging: Definition of standardized anatomic imaging planes to monitor coronary arteries (single oblique, volume targeted). Optimization of acquisition window with respect to various heart frequencies. Evaluation of the influence of the position of the navigator and tracking factor on image quality. Optimization of a pulse triggered protocol. Evaluation of black-blood coronary imaging and visualization of the lumen and wall of coronary arteries.
5. Phase contrast techniques: Optimization of imaging planes, time resolution and spatial resolution of flow measurements in the heart, in the vessels around the heart, lung vessels and coronary arteries. Evaluation of retrospective and prospective gating with respect to the heart frequency. Evaluation of normal values in 1-dimensional, 2-dimensional and 3-dimensional time resolved flow measurements.
6. Single-Shot Imaging: Evaluation of signal intensity and stability of single shot techniques with and without preparation pulses. Optimization of real-time image acquisition.
7. Parallel acquisition and breath-hold time optimization: Evaluation of impact of echo-sharing and parallel acquisition on image quality. Optimization of short-breath-hold protocols.

Conditions

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Sequence Optimization Protocol Optimization Normal Values Feasibility

Eligibility Criteria

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Inclusion Criteria

* No history of cardiac or pulmonary diseases
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Medical University of Graz

OTHER

Sponsor Role lead

Responsible Party

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Ursula Reiter

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gert Reiter, DI Dr.

Role: PRINCIPAL_INVESTIGATOR

Siemens Medical Solutions

Ursula Reiter, DI Dr.

Role: PRINCIPAL_INVESTIGATOR

University Hospital Graz

Locations

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Medical Unitersity Graz, Allgemeine Radiologische Diagnostik

Graz, Stmk, Austria

Site Status

Countries

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Austria

References

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Reiter G, Reiter U, Bergmann P, Rienmuller R. MR imaging-based port placement planning for totally endoscopic coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2004 Jun;3(2):341-5. doi: 10.1016/j.icvts.2004.01.015.

Reference Type RESULT
PMID: 17670255 (View on PubMed)

Reiter G, Reiter U, Rienmuller R, Gagarina N, Ryabikin A. On the value of geometry-based models for left ventricular volumetry in magnetic resonance imaging and electron beam tomography: a Bland-Altman analysis. Eur J Radiol. 2004 Nov;52(2):110-8. doi: 10.1016/j.ejrad.2003.10.003.

Reference Type RESULT
PMID: 15489068 (View on PubMed)

Reiter G, Reiter U, Kovacs G, Kainz B, Schmidt K, Maier R, Olschewski H, Rienmueller R. Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure. Circ Cardiovasc Imaging. 2008 Jul;1(1):23-30. doi: 10.1161/CIRCIMAGING.108.780247.

Reference Type RESULT
PMID: 19808511 (View on PubMed)

Other Identifiers

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CMR-02-TECH-01

Identifier Type: -

Identifier Source: org_study_id