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Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

NCT ID: NCT00382369

Last Updated: 2017-02-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

11 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-06-01

Study Completion Date

2008-12-29

Brief Summary

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Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

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Detailed Description

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In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.

Conditions

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Vocal Cord Paralysis

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* members of families suffering of familial vocal cord paralysis

Exclusion Criteria

* none
Minimum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hadassah Medical Organization

OTHER

Sponsor Role lead

Responsible Party

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Kerem Eithan

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Eitan Kerem, MD

Role: STUDY_DIRECTOR

Hadassah MO

Batsheva Kerem, PhD

Role: PRINCIPAL_INVESTIGATOR

Hebrew University Jerusalem

Locations

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Hadassah-Hebrew University Medical Center, Mt Scopus

Jerusalem, , Israel

Site Status

Countries

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Israel

References

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Manaligod JM, Skaggs J, Smith RJ. Localization of the gene for familial laryngeal abductor paralysis to chromosome 6q16. Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):913-7. doi: 10.1001/archotol.127.8.913.

Reference Type BACKGROUND
PMID: 11493198 (View on PubMed)

Other Identifiers

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VOCALCORD-HMO-CTIL

Identifier Type: -

Identifier Source: org_study_id

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