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Comparison of Dialysis Strategies in Critically Ill Patients With Acute Renal Failure

NCT ID: NCT00322530

Last Updated: 2012-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

230 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-04-30

Study Completion Date

2009-02-28

Brief Summary

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The goal of the present study is the comparison of different dialysis strategies in critically ill patients with acute renal failure on the intensive care unit. Patients are treated with either continuous dialysis or hemofiltration. Outcome measures are death, restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.

Detailed Description

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The goal of the present study is the comparison of different renal replacement strategies in critically ill patients with acute renal failure on the intensive care unit. In a prospectively randomized clinical study patients are treated with either continuous dialysis (SLED) or continuous hemofiltration (CVVHD). 200 patients should be included in the study (n=100 each). The primary outcome is death at ICU, secondary outcome measures are restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.

Conditions

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Dialysis Acute Renal Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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SLED

Group Type ACTIVE_COMPARATOR

Renal replacement therapy

Intervention Type PROCEDURE

ICU patients with acute renal failure were prospectively randomized to either CVVHD or SLED

CVVHD

Group Type ACTIVE_COMPARATOR

Renal replacement therapy

Intervention Type PROCEDURE

ICU patients with acute renal failure were prospectively randomized to either CVVHD or SLED

Interventions

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Renal replacement therapy

ICU patients with acute renal failure were prospectively randomized to either CVVHD or SLED

Intervention Type PROCEDURE

Other Intervention Names

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sustained low efficiency dialysis (SLED) continous veno-venous hemodiafiltration (CVVHD)

Eligibility Criteria

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Inclusion Criteria

* Patients 18 years or older
* Written informed consent
* No pre-existing dialysis dependency

Exclusion Criteria

* Minors / children
* No consent
* Severe electrolyte disturbances which necessitates special dialysis therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Heidelberg University

OTHER

Sponsor Role lead

Responsible Party

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Vedat Schwenger M.D

Prof. Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Vedat Schwenger, MD

Role: PRINCIPAL_INVESTIGATOR

Division of Nephrology, University of Heidelberg

Locations

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Division of Nephrology, University of Heidelberg

Heidelberg, Baden-Wurttemberg, Germany

Site Status

Countries

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Germany

References

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Fayad AI, Buamscha DG, Ciapponi A. Timing of kidney replacement therapy initiation for acute kidney injury. Cochrane Database Syst Rev. 2022 Nov 23;11(11):CD010612. doi: 10.1002/14651858.CD010612.pub3.

Reference Type DERIVED
PMID: 36416787 (View on PubMed)

Tsujimoto Y, Miki S, Shimada H, Tsujimoto H, Yasuda H, Kataoka Y, Fujii T. Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2021 Sep 14;9(9):CD013330. doi: 10.1002/14651858.CD013330.pub2.

Reference Type DERIVED
PMID: 34519356 (View on PubMed)

Schwenger V, Weigand MA, Hoffmann O, Dikow R, Kihm LP, Seckinger J, Miftari N, Schaier M, Hofer S, Haar C, Nawroth PP, Zeier M, Martin E, Morath C. Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts. Crit Care. 2012 Jul 27;16(4):R140. doi: 10.1186/cc11445.

Reference Type DERIVED
PMID: 22839577 (View on PubMed)

Other Identifiers

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HD-Dialysis-2006

Identifier Type: -

Identifier Source: org_study_id