Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients

NCT ID: NCT01228123

Last Updated: 2011-05-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

252 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-01-31

Study Completion Date

2008-01-31

Brief Summary

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The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

Detailed Description

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please see above

Conditions

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Acute Renal Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CVVH arm

Group Type ACTIVE_COMPARATOR

RRT for acute kidney failure using the CVVH method

Intervention Type OTHER

patients randomized to receive CVVH

IHD arm

Group Type ACTIVE_COMPARATOR

RRT for acute kidney failure using the IHD (intermittent HD)

Intervention Type OTHER

patients randomized to receive IHD

Interventions

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RRT for acute kidney failure using the CVVH method

patients randomized to receive CVVH

Intervention Type OTHER

RRT for acute kidney failure using the IHD (intermittent HD)

patients randomized to receive IHD

Intervention Type OTHER

Other Intervention Names

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does not apply does not apply

Eligibility Criteria

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Inclusion Criteria

* all ICU patients requiring renal replacement therapy

Exclusion Criteria

* patient denies informed consent
* patient not requiring intensive care therapy
* kidney transplanted patients
* chronic renal failure (serum creatinine \> 3mg/dl)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Charite University Medicine

Principal Investigators

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Achim Joerres, MD

Role: PRINCIPAL_INVESTIGATOR

Charite University Medicine

Locations

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Charite University Medicine

Berlin, State of Berlin, Germany

Site Status

Countries

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Germany

References

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Tsujimoto Y, Miki S, Shimada H, Tsujimoto H, Yasuda H, Kataoka Y, Fujii T. Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2021 Sep 14;9(9):CD013330. doi: 10.1002/14651858.CD013330.pub2.

Reference Type DERIVED
PMID: 34519356 (View on PubMed)

Schefold JC, von Haehling S, Pschowski R, Bender T, Berkmann C, Briegel S, Hasper D, Jorres A. The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trial. Crit Care. 2014 Jan 10;18(1):R11. doi: 10.1186/cc13188.

Reference Type DERIVED
PMID: 24405734 (View on PubMed)

Other Identifiers

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CONVINT

Identifier Type: -

Identifier Source: org_study_id

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