The Regulation of Osteoprotegerin by Mechanical Stimulation
NCT ID: NCT00155311
Last Updated: 2013-03-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
10 participants
INTERVENTIONAL
2005-01-31
Brief Summary
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Detailed Description
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Changes OPG expression of osteoblasts under mechanical stimulation can play a role in bone remodeling. In order to test this hypothesis, the following specific aims will be achieved:
1. To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.
2. To optimize the regulation by changing magnitude and frequency of pressure, and characterize the time table for these changes..
Conditions
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Study Design
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NON_RANDOMIZED
FACTORIAL
TREATMENT
SINGLE
Study Groups
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days after treatment
different days after orthodontic treament, samples will be taken.
orthodontic treatment
Interventions
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orthodontic treatment
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
35 Years
ALL
Yes
Sponsors
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National Science and Technology Council, Taiwan
OTHER_GOV
National Taiwan University Hospital
OTHER
Responsible Party
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Principal Investigators
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Chung-Chen Yao, DDS, PhD
Role: PRINCIPAL_INVESTIGATOR
National Taiwan University Hospital
Locations
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Department of Dentistry, National Taiwan University Hospital
Taipei, , Taiwan
Countries
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Other Identifiers
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9361700741
Identifier Type: -
Identifier Source: org_study_id
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