Clinical Trials

Showing trials with last updates posted in 2025.

NCT06525532 | RECRUITING
35 Participants

Clinical-MRI Evaluation in Patients Undergoing Subtalar Arthrorisis With Reabsorbable Endorthesis Implant in PLLA

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-06-12
Completion: 2026-11-30
Conditions
Lower Limb Deformity
Interventions
OTHER
No Results Yet
NCT06522932 | RECRUITING | PHASE1
32 Participants

PET Imaging Study of 64Cu-GRIP B for Patients Receiving CD19-directed CAR-T Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-10-23
Completion: 2027-01-31
Conditions
Non Hodgkin Lymphoma
Interventions
DRUG PROCEDURE
No Results Yet
NCT06516874 | RECRUITING | NA
13 Participants

A Pilot Study of Trauma-Focused Cognitive-Behavioral Therapy for Treatment of Post-traumatic Stress in Adults.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-10-22
Completion: 2026-02-28
Conditions
Post Traumatic Stress Disorder Complex Post-Traumatic Stress Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT06510998 | RECRUITING | NA
390 Participants

Isometric Resistance Exercise for Hypertension

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2025-01-01
Completion: 2027-07-28
Conditions
Hypertension
Interventions
BEHAVIORAL
No Results Yet
NCT06494189 | COMPLETED | PHASE1
9 Participants

Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically Resectable Head and Neck Squamous Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-07-31
Completion: 2025-04-10
Conditions
Head and Neck Cancer
Interventions
BIOLOGICAL DRUG RADIATION
No Results Yet
NCT06492434 | COMPLETED | NA
16 Participants

Enhancing Community Participation Through Peer-Delivered Decision Support

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-07-01
Completion: 2025-08-31
Conditions
Severe Mental Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT06475989 | RECRUITING | PHASE3
264 Participants

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-08-22
Completion: 2030-09-30
Conditions
Refractory Differentiated Thyroid Gland Carcinoma
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT06475235 | RECRUITING | PHASE1
15 Participants

Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-10-18
Completion: 2025-12-30
Conditions
Lymphoma Primary Central Nervous System Lymphoma
Interventions
DRUG
No Results Yet
NCT06470815 | ENROLLING_BY_INVITATION
400 Participants

ROADSTER 3 Extended Follow-up Sub-Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-07-31
Completion: 2029-07-31
Conditions
Carotid Artery Diseases
Interventions
PROCEDURE
No Results Yet
NCT06446661 | NOT_YET_RECRUITING | NA
38 Participants

Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2025-12-15
Completion: 2027-06-15
Conditions
Acute Lymphoblastic Leukemia
Interventions
OTHER
No Results Yet
NCT06431815 | ACTIVE_NOT_RECRUITING
228 Participants

ADVENT Post Approval Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-09-25
Completion: 2028-10-31
Conditions
Paroxysmal Atrial Fibrillation
Interventions
DEVICE
No Results Yet
NCT06425549 | RECRUITING | PHASE3
168 Participants

A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-06-25
Completion: 2028-08-21
Conditions
Moderate to Severe Plaque Psoriasis
Interventions
DRUG
No Results Yet
NCT06414967 | RECRUITING | NA
15 Participants

Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-10-15
Completion: 2026-07-31
Conditions
Huntington Disease
Interventions
OTHER
No Results Yet
NCT06400706 | COMPLETED | NA
92 Participants

Effect of Electroencephalography Guided General Anesthesia on Postoperative Delirium in Children

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-05-15
Completion: 2024-12-15
Conditions
Postoperative Delirium Postoperative Pain
Interventions
PROCEDURE
No Results Yet
NCT06380660 | RECRUITING | PHASE1/PHASE2
298 Participants

Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-03-22
Completion: 2028-12-21
Conditions
Solid Tumor, Adult BRCA1 Mutation BRCA2 Mutation Ovarian Cancer Breast Cancer Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06378528 | SUSPENDED | EARLY_PHASE1
5 Participants

Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2026-03-31
Completion: 2027-03-31
Conditions
Posttraumatic Stress Disorder
Interventions
DRUG DEVICE
No Results Yet
NCT06373159 | ACTIVE_NOT_RECRUITING
5740 Participants

An Observational Study to Learn About the Occurrence of Disseminated Intravascular Coagulation Among Adults With Sepsis in Japan

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-03-22
Completion: 2025-12-31
Conditions
Sepsis Disseminated Intravascular Coagulation
Interventions
OTHER
No Results Yet
NCT06367465 | RECRUITING
50 Participants

Feasibility and Acceptability of HCV Treatment in Pregnancy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-02-01
Completion: 2026-02-28
Conditions
Hepatitis C Pregnancy Complications
Interventions
DRUG
No Results Yet
NCT06350890 | COMPLETED | PHASE3
408 Participants

Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2023-11-05
Completion: 2024-12-12
Conditions
T2DM (Type 2 Diabetes Mellitus)
Interventions
DRUG
No Results Yet
NCT06343870 | RECRUITING | PHASE3
140 Participants

Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2025-12-18
Completion: 2026-08-18
Conditions
Menopause Testosterone Deficiency Estrogen Deficiency
Interventions
DRUG
No Results Yet
NCT06342375 | RECRUITING | NA
425000 Participants

Enrollment Barriers, Procedural Denials, and Loss of Medicaid Coverage

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2025-02-12
Completion: 2026-09-30
Conditions
No Medicaid Coverage
Interventions
OTHER
No Results Yet
NCT06340360 | ACTIVE_NOT_RECRUITING | PHASE2
94 Participants

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-04-02
Completion: 2025-11-26
Conditions
Alopecia Areata
Interventions
DRUG
No Results Yet
NCT06335524 | RECRUITING | NA
188 Participants

Infant-Maternal Partnership and Cognitive Training Study for Preterm Infants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-11-01
Completion: 2026-12-31
Conditions
Child Development Infant Development Infant, Premature, Diseases
Interventions
BEHAVIORAL
No Results Yet
NCT06334016 | NOT_YET_RECRUITING | EARLY_PHASE1
60 Participants

Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2026-02-15
Completion: 2028-03-01
Conditions
Cannabis Dependence
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT06320405 | RECRUITING | PHASE1/PHASE2
38 Participants

Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-05-21
Completion: 2027-04-01
Conditions
Advanced Malignant Solid Neoplasm Metastatic Malignant Solid Neoplasm Recurrent Malignant Solid Neoplasm Refractory Malignant Solid Neoplasm
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT06305949 | RECRUITING | NA
30 Participants

Clinical Trial on the Safety and Efficacy of Optimized Transcranial Direct Current Stimulation for the Swallowing Function in Patients With Post-Stroke Dysphagia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-04-22
Completion: 2026-02-28
Conditions
Deglutition Disorders
Interventions
DEVICE
No Results Yet
NCT06291285 | COMPLETED | PHASE1
44 Participants

A Study to Test How Either a Capsule or a Tablet With NDec (Decitabine and Tetrahydrouridine) Works in the Body of Healthy People

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-02-27
Completion: 2024-06-10
Conditions
Healthy Volunteers
Interventions
DRUG
No Results Yet
NCT06285760 | RECRUITING
64 Participants

Effect of Acetazolamide on Diuresis and Natriuresis in Patients With Acute Heart Failure (SANDI STUDY)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-03-01
Completion: 2026-05-31
Conditions
Heart Failure Persistent Congestion
Interventions
DRUG
No Results Yet
NCT06271265 | RECRUITING | PHASE1
48 Participants

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-03-29
Completion: 2027-01-31
Conditions
Postoperative Pain
Interventions
DRUG
No Results Yet
NCT06257264 | RECRUITING | PHASE1
258 Participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-03-11
Completion: 2028-04-30
Conditions
Breast Cancer Small Cell Lung Cancer Ovarian Cancer Gastric Cancer Hormone-receptor-positive Breast Cancer Hormone Receptor Positive HER-2 Negative Breast Cancer Advanced Solid Tumor Endometrial Cancer Prostate Cancer TNBC - Triple-Negative Breast Cancer GastroEsophageal Cancer Bladder Cancer
Interventions
DRUG
No Results Yet
NCT06251986 | COMPLETED
310 Participants

A Cross-sectional Study to Assess the Effectiveness and Safety of Ofatumumab (Kesimpta®) in Patients With Relapsing Multiple Sclerosis in the Spanish Clinical Practice

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-02-26
Completion: 2024-12-23
Conditions
Relapsing Forms of Multiple Sclerosis
Interventions
OTHER
No Results Yet
NCT06249178 | RECRUITING
1000 Participants

EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-07-02
Completion: 2028-09-01
Conditions
Preeclampsia
No Results Yet
NCT06221839 | NOT_YET_RECRUITING
72 Participants

Structural Racism, Reward Related Decision Making and Substance Use Risk

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2026-01-31
Completion: 2026-07-31
Conditions
Structural Racism Substance Use Risk
No Results Yet
NCT06193863 | RECRUITING
50 Participants

An Observational Study to Learn More About How Safe Rivaroxaban is And How Well it Works in Children With Congenital Heart Disease Who Had a Heart Surgery Called the Fontan Procedure

Study Type: OBSERVATIONAL
Last Updated: 2025-12-29
Start Date: 2024-06-18
Completion: 2026-06-30
Conditions
Prevention of Venous Thromboembolism Congenital Heart Disease Fontan Procedure Children
Interventions
DRUG
No Results Yet
NCT06193057 | RECRUITING | NA
24 Participants

Comparison of Customized and Standard Total Ankle Prostheses

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2023-07-26
Completion: 2026-04-30
Conditions
Ankle Osteoarthritis
Interventions
PROCEDURE
No Results Yet
NCT06173063 | TERMINATED | NA
19 Participants

Safety and Effectiveness of A Novel Enteral Feeding System: Prospective Study.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2023-11-14
Completion: 2024-11-06
Conditions
Enteral Feeding
Interventions
DEVICE
NCT06147531 | RECRUITING | PHASE2
150 Participants

Delayed Cold-Stored Platelets -PLTS-1

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-06-05
Completion: 2026-06-30
Conditions
Platelets Bleeding Cardiopulmonary Bypass Cardiac Surgery
Interventions
BIOLOGICAL
No Results Yet
NCT06120283 | RECRUITING | PHASE1
300 Participants

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2023-12-01
Completion: 2028-06-30
Conditions
Advanced Solid Tumor Advanced Breast Cancer Metastatic Breast Cancer Hormone-receptor-positive Breast Cancer Hormone Receptor Positive Breast Carcinoma Hormone Receptor Positive Malignant Neoplasm of Breast HER2-negative Breast Cancer Hormone Receptor Positive HER-2 Negative Breast Cancer Non-small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT06100744 | RECRUITING | PHASE3
40 Participants

A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-07-08
Completion: 2026-09-30
Conditions
Juvenile Psoriatic Arthritis
Interventions
DRUG
No Results Yet
NCT06095128 | RECRUITING | PHASE4
65 Participants

A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-29
Start Date: 2024-06-12
Completion: 2027-07-09
Conditions
Ulcerative Colitis
Interventions
DRUG
No Results Yet
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