Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia

NCT ID: NCT06446661

Last Updated: 2025-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-15

Study Completion Date

2028-06-15

Brief Summary

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The purpose of this section is to learn how text message reminders might help with regularly taking chemotherapy medications for Adolescents and Adults with Acute Lymphoblastic leukemia (ALL).

Detailed Description

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This study aims to compare adherence to oral mercaptopurine and methotrexate during the first 84-day cycle of maintenance therapy for adolescent and young adult patients with Acute Lymphoblastic Leukemia on pediatric-based regimens between those who receive the high intensity text message intervention and those who receive standard-of-care. It is believed that high-intensity text messages will increase patient adherence within cycle 1.

Conditions

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Acute Lymphoblastic Leukemia

Keywords

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Oral Chemotherapy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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High Intensity

Receives high-intensity text messaging for 2 cycles of treatment

Group Type ACTIVE_COMPARATOR

High Intensity

Intervention Type OTHER

Daily texts

Low Intensity

Receives no texts for 1st cycle and low-intensity texts for 2nd cycle

Group Type ACTIVE_COMPARATOR

No Text Messagings

Intervention Type OTHER

Standard Care

Low Intensity Text Messaging

Intervention Type OTHER

Weekly Texts

Interventions

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High Intensity

Daily texts

Intervention Type OTHER

No Text Messagings

Standard Care

Intervention Type OTHER

Low Intensity Text Messaging

Weekly Texts

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age of 15-39 years-old at the time of initial ALL diagnosis
* Diagnosed with ALL
* Currently receiving treatment with pediatric-based regimen that includes maintenance with mercaptopurine and methotrexate (e.g., CALGB 10403). Study participation begins with the start of maintenance, so enrollment occurs prior to the start of maintenance.

Exclusion Criteria

* Patient or caregiver who would receive text message reminders does not have a cell phone that receives text messages
* Patient does not wish to participate
* Text messages will be crafted in the patient's preferred language for medical communication, so English fluency is not an enrollment requirement.
Minimum Eligible Age

15 Years

Maximum Eligible Age

39 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Chicago

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wendy Stock

Role: PRINCIPAL_INVESTIGATOR

University of Chicago

Locations

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University of Chicago Medicine Comprehensive Cancer Center

Chicago, Illinois, United States

Site Status

Countries

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United States

Central Contacts

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Clinical Trials Intake

Role: CONTACT

Phone: 1-855-702-8222

Email: [email protected]

Facility Contacts

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Clinical Trials Intake

Role: primary

Other Identifiers

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IRB23-1519

Identifier Type: -

Identifier Source: org_study_id