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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05284513 | ENROLLING_BY_INVITATION | NA
532 Participants

Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-09
Completion: 2027-01-31
Conditions
Familial Hypercholesterolemia
Interventions
BEHAVIORAL
No Results Yet
NCT05271409 | RECRUITING | PHASE3
152 Participants

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-30
Completion: 2025-11-20
Conditions
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
Interventions
DRUG OTHER
No Results Yet
NCT05268289 | RECRUITING | PHASE2
240 Participants

Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-10
Completion: 2026-03-30
Conditions
Lupus Nephritis
Interventions
DRUG
No Results Yet
NCT05258435 | ACTIVE_NOT_RECRUITING
131 Participants

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-09
Completion: 2028-04-30
Conditions
Cervical Disc Disease Degenerative Disc Disease
Interventions
DEVICE
No Results Yet
NCT05241860 | ACTIVE_NOT_RECRUITING | PHASE2
79 Participants

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-21
Completion: 2025-09-29
Conditions
Castration-Sensitive Prostate Carcinoma Metastatic Prostate Carcinoma Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8
Interventions
OTHER
No Results Yet
NCT05235165 | RECRUITING | PHASE3
250 Participants

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-01
Completion: 2031-03-31
Conditions
Metastatic Malignant Neoplasm in the Lung Metastatic Osteosarcoma Osteosarcoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT05228275 | ACTIVE_NOT_RECRUITING
549 Participants

Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-08
Completion: 2027-09-30
Conditions
COVID-19 Infection Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm
Interventions
PROCEDURE OTHER
No Results Yet
NCT05218655 | COMPLETED | PHASE3
101 Participants

A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-22
Completion: 2025-04-15
Conditions
Inherited Mitochondrial Disease
Interventions
DRUG
Results Available
NCT05202093 | COMPLETED | NA
129 Participants

Efficacy of Two Sonic Toothbrushes in Reducing Extrinsic Tooth Stain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-05
Completion: 2022-07-15
Conditions
Tooth Bleaching
Interventions
DEVICE
Results Available
NCT05199688 | RECRUITING | PHASE3
8 Participants

A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-12-31
Completion: 2027-03-31
Conditions
Neuromyelitis Optica Spectrum Disorder NMOSD
Interventions
DRUG
No Results Yet
NCT05193396 | RECRUITING | PHASE4
100 Participants

Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-01
Completion: 2026-01-31
Conditions
Adrenal Insufficiency Polymyalgia Rheumatica (PMR) Giant Cell Arteritis (GCA)
Interventions
DRUG
No Results Yet
NCT05187429 | RECRUITING | PHASE1/PHASE2
42 Participants

Low Dose Nivolumab in Adults Living With HIV on Antiretroviral Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-01-24
Completion: 2029-01-31
Conditions
HIV I Infection
Interventions
DRUG
No Results Yet
NCT05174780 | COMPLETED | NA
159 Participants

Myopia Control With a Innovative Spectacle Lens

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-29
Completion: 2025-10-20
Conditions
Myopia
Interventions
DEVICE
No Results Yet
NCT05173844 | COMPLETED | NA
128 Participants

Digital Sleep Therapy for Older Adults With Cognitive Impairment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-10
Completion: 2025-07-01
Conditions
Insomnia Type; Sleep Disorder Cognitive Impairment
Interventions
OTHER
No Results Yet
NCT05172973 | RECRUITING | NA
200 Participants

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-11-22
Completion: 2026-12-31
Conditions
Aortic Valve Insufficiency Aortic Valve Stenosis
Interventions
DEVICE
No Results Yet
NCT05171686 | COMPLETED | PHASE4
49 Participants

Diuretics and Volume Overload in Early CKD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-02-01
Completion: 2025-10-02
Conditions
Chronic Kidney Disease Hypertension
Interventions
DRUG
No Results Yet
NCT05167045 | COMPLETED
20 Participants

A Pilot Study for the Brain Health Support Program

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-11-15
Completion: 2022-04-29
Conditions
Dementia Mild Cognitive Impairment Subjective Cognitive Impairment Pre-dementia Dementia Prevention
Interventions
BEHAVIORAL
No Results Yet
NCT05152524 | ACTIVE_NOT_RECRUITING | NA
168 Participants

Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-25
Completion: 2025-12-31
Conditions
Ischemic Stroke Neovascularization
Interventions
DEVICE
No Results Yet
NCT05126277 | RECRUITING | PHASE3
462 Participants

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-07-14
Completion: 2027-06-22
Conditions
Lupus Nephritis
Interventions
DRUG
No Results Yet
NCT05124119 | COMPLETED
65 Participants

Strategies to Enhance Recruitment and Retention of Black Individuals Into Clinical Trials for Substance Use Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-01
Completion: 2022-12-01
Conditions
Substance Use Disorders
No Results Yet
NCT05123196 | COMPLETED | PHASE2
156 Participants

Exploratory Study of MT-8554 in Subjects With Painful Diabetic Peripheral Neuropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-11-16
Completion: 2022-11-01
Conditions
Painful Diabetic Peripheral Neuropathy
Interventions
DRUG
No Results Yet
NCT05120570 | COMPLETED | PHASE1/PHASE2
16 Participants

PTCy + Sirolimus/VIC-1911 as GVHD Prophylaxis in Myeloablative PBSC Transplantation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-17
Completion: 2024-09-19
Conditions
Acute Leukemia Myelodysplastic Syndromes Myeloproliferative Neoplasm Lymphoma
Interventions
DRUG
Results Available
NCT05119296 | ACTIVE_NOT_RECRUITING | PHASE2
12 Participants

Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-15
Completion: 2025-05-16
Conditions
Thyroid Cancer
Interventions
DRUG
No Results Yet
NCT05117307 | NOT_YET_RECRUITING | NA
60 Participants

Comparison of Transversalis Fascia Plane Block and Erector Spinae Plane Blocks in Cesarean Section

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-12-20
Completion: 2026-06-15
Conditions
Pain Postoperative Pain
Interventions
DRUG
No Results Yet
NCT05094336 | RECRUITING | PHASE1/PHASE2
649 Participants

A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-01
Completion: 2026-07-02
Conditions
Advanced MTAP-null Solid Tumors
Interventions
DRUG
No Results Yet
NCT05089227 | RECRUITING | PHASE2
72 Participants

Efficacy of Prolonged Anticoagulation for Primary Prevention of Venous Thromboembolic Disease in Autoimmune Hemolytic Anemia: a Prospective, Phase II, Randomized, Multicenter Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-03
Completion: 2028-08-31
Conditions
Prolonged Anticoagulation Venous Thromboembolic Disease Autoimmune Hemolytic Anemia
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05081245 | ACTIVE_NOT_RECRUITING | PHASE2
150 Participants

ML-004 in Adolescents and Adults With Autism Spectrum Disorders (ASD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-13
Completion: 2026-10-31
Conditions
Autism Spectrum Disorder
Interventions
DRUG
No Results Yet
NCT05080764 | ACTIVE_NOT_RECRUITING | PHASE2
126 Participants

Study to Evaluate the Safety and Efficacy of BF-200 ALA (Ameluz®) and BF-RhodoLED® in the Treatment of Moderate to Severe Acne Vulgaris With Photodynamic Therapy in Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-10
Completion: 2025-08-22
Conditions
Acne Vulgaris
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05080465 | COMPLETED | PHASE3
700 Participants

Long Term Follow up Mesenchymal Stem Cell Therapy for Patients Virus-related Liver Cirrhosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2018-12-02
Completion: 2024-10-07
Conditions
Liver Cirrhosis
Interventions
BIOLOGICAL
No Results Yet
NCT05075824 | ACTIVE_NOT_RECRUITING | PHASE2
90 Participants

A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-09
Completion: 2025-06-11
Conditions
Sickle Cell Disease
Interventions
DRUG
No Results Yet
NCT05074277 | COMPLETED | NA
20 Participants

Skeletal Response to Simulated Night Shift

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-08
Completion: 2025-12-18
Conditions
Osteoporosis Circadian Rhythm Sleep Disorder, Shift Work Type
Interventions
BEHAVIORAL
No Results Yet
NCT05069038 | ACTIVE_NOT_RECRUITING | PHASE2
51 Participants

Clinical Trial Assessing the Safety of Neoadjuvant Palbociclib in Combination With Endocrine Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-02
Completion: 2026-09-30
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT05067569 | COMPLETED | NA
270 Participants

App-delivered Sleep ThERapy for Older Individuals With Insomnia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-01
Completion: 2025-01-31
Conditions
Insomnia
Interventions
BEHAVIORAL
No Results Yet
NCT05066711 | ENROLLING_BY_INVITATION
75 Participants

NuVasive® ACP System Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-05-22
Completion: 2026-09-30
Conditions
Cervical Spondylosis Cervical Radiculopathy Cervical Myelopathy Cervical Disc Disease Cervical Stenosis Cervical Disc Herniation Cervical Spine Disease
No Results Yet
NCT05063565 | ACTIVE_NOT_RECRUITING | PHASE2
100 Participants

TheraSphere With Durvalumab and Tremelimumab for HCC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-11-03
Completion: 2027-06-30
Conditions
Hepatocellular Carcinoma
Interventions
DEVICE DRUG
No Results Yet
NCT05060016 | ACTIVE_NOT_RECRUITING | PHASE2
222 Participants

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-01
Completion: 2026-12-30
Conditions
Relapsed/Refractory Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05039151 | COMPLETED
26 Participants

Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-25
Completion: 2025-07-19
Conditions
Interstitial Liquid Septic Shock
Interventions
BIOLOGICAL
No Results Yet
NCT05035836 | RECRUITING | PHASE2
20 Participants

A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-11-16
Completion: 2028-12-29
Conditions
Breast Cancer HER2-positive
Interventions
DRUG
No Results Yet
NCT05014204 | COMPLETED | NA
20 Participants

Safety and Feasibility of Novel Therapy for Duodenal Mucosal Regeneration for Type II Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-10-29
Completion: 2024-05-29
Conditions
Diabetes Diabetes Type 2 Diabetes Mellitus, Type 2 Glucose Metabolism Disorders Metabolic Disease Endocrine System Diseases Diabetes Mellitus
Interventions
DEVICE
Results Available
NCT04996628 | RECRUITING | NA
150 Participants

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-01-04
Completion: 2026-06-30
Conditions
Chronic Pancreatitis Chronic Pain
Interventions
DIAGNOSTIC_TEST
No Results Yet
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