Clinical Trials Updated in 2025

NCT05352672 | ACTIVE_NOT_RECRUITING | PHASE3

1546 Participants

Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-07-14

Completion: 2026-03-16

Conditions

Melanoma

Interventions

DRUG

No Results Yet

NCT05350072 | ACTIVE_NOT_RECRUITING | PHASE3

276 Participants

Two-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-07-28

Completion: 2025-05-07

Conditions

Sjogren Syndrome

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT05349214 | ACTIVE_NOT_RECRUITING | PHASE3

506 Participants

Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-08-04

Completion: 2025-05-13

Conditions

Sjogren Syndrome

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT05342753 | COMPLETED | NA

22 Participants

Safety and Effectiveness of Restylane® Kysse for Lip Augmentation in Chinese Subjects

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-06-13

Completion: 2024-10-25

Conditions

Lip Augmentation

Interventions

DEVICE

Results Available

NCT05337618 | RECRUITING | PHASE2

72 Participants

Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-12-16

Completion: 2026-09-01

Conditions

Traumatic Brain Injury

Interventions

DIAGNOSTIC_TEST COMBINATION_PRODUCT

No Results Yet

NCT05320367 | NOT_YET_RECRUITING | PHASE1/PHASE2

80 Participants

A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2026-09-30

Completion: 2027-10-31

Conditions

Cannabis

Interventions

DRUG

No Results Yet

NCT05318924 | COMPLETED | PHASE1/PHASE2

26 Participants

Effects of Ghrelin Administration on Dopamine and Effort

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-02-21

Completion: 2024-08-06

Conditions

Major Depressive Disorder

Interventions

DRUG OTHER

No Results Yet

NCT05317416 | ACTIVE_NOT_RECRUITING | PHASE3

811 Participants

Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-03-25

Completion: 2027-08-04

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05304585 | RECRUITING | PHASE3

205 Participants

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-08-04

Completion: 2030-06-30

Conditions

Embryonal Rhabdomyosarcoma Fusion-Negative Alveolar Rhabdomyosarcoma Spindle Cell/Sclerosing Rhabdomyosarcoma

Interventions

PROCEDURE DRUG BIOLOGICAL RADIATION

No Results Yet

NCT05288543 | TERMINATED | PHASE1

63 Participants

A Study of Orally Administered IPG7236 in Healthy Adult Participants

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-04-07

Completion: 2023-03-31

Conditions

Atopic Dermatitis

Interventions

DRUG OTHER

No Results Yet

NCT05284513 | ENROLLING_BY_INVITATION | NA

532 Participants

Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-09-09

Completion: 2027-01-31

Conditions

Familial Hypercholesterolemia

Interventions

BEHAVIORAL

No Results Yet

NCT05268289 | RECRUITING | PHASE2

240 Participants

Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-08-10

Completion: 2026-03-30

Conditions

Lupus Nephritis

Interventions

DRUG

No Results Yet

NCT05258435 | ACTIVE_NOT_RECRUITING

131 Participants

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2022-02-09

Completion: 2028-04-30

Conditions

Cervical Disc Disease Degenerative Disc Disease

Interventions

DEVICE

No Results Yet

NCT05241860 | ACTIVE_NOT_RECRUITING | PHASE2

79 Participants

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-11-21

Completion: 2025-09-29

Conditions

Castration-Sensitive Prostate Carcinoma Metastatic Prostate Carcinoma Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8

Interventions

OTHER

No Results Yet

NCT05235165 | RECRUITING | PHASE3

250 Participants

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-04-01

Completion: 2031-03-31

Conditions

Metastatic Malignant Neoplasm in the Lung Metastatic Osteosarcoma Osteosarcoma

Interventions

PROCEDURE OTHER

No Results Yet

NCT05228275 | ACTIVE_NOT_RECRUITING

549 Participants

Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2022-04-08

Completion: 2027-09-30

Conditions

COVID-19 Infection Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm

Interventions

PROCEDURE OTHER

No Results Yet

NCT05218655 | COMPLETED | PHASE3

101 Participants

A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-06-22

Completion: 2025-04-15

Conditions

Inherited Mitochondrial Disease

Interventions

DRUG

Results Available

NCT05202093 | COMPLETED | NA

129 Participants

Efficacy of Two Sonic Toothbrushes in Reducing Extrinsic Tooth Stain

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-03-05

Completion: 2022-07-15

Conditions

Tooth Bleaching

Interventions

DEVICE

Results Available

NCT05193396 | RECRUITING | PHASE4

100 Participants

Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-02-01

Completion: 2026-01-31

Conditions

Adrenal Insufficiency Polymyalgia Rheumatica (PMR) Giant Cell Arteritis (GCA)

Interventions

DRUG

No Results Yet

NCT05187429 | RECRUITING | PHASE1/PHASE2

42 Participants

Low Dose Nivolumab in Adults Living With HIV on Antiretroviral Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2023-01-24

Completion: 2029-01-31

Conditions

HIV I Infection

Interventions

DRUG

No Results Yet

NCT05174780 | COMPLETED | NA

159 Participants

Myopia Control With a Innovative Spectacle Lens

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2021-12-29

Completion: 2025-10-20

Conditions

Myopia

Interventions

DEVICE

No Results Yet

NCT05173844 | COMPLETED | NA

128 Participants

Digital Sleep Therapy for Older Adults With Cognitive Impairment

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-11-10

Completion: 2025-07-01

Conditions

Insomnia Type; Sleep Disorder Cognitive Impairment

Interventions

OTHER

No Results Yet

NCT05172973 | RECRUITING | NA

200 Participants

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2023-11-22

Completion: 2026-12-31

Conditions

Aortic Valve Insufficiency Aortic Valve Stenosis

Interventions

DEVICE

No Results Yet

NCT05171686 | COMPLETED | PHASE4

49 Participants

Diuretics and Volume Overload in Early CKD

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2023-02-01

Completion: 2025-10-02

Conditions

Chronic Kidney Disease Hypertension

Interventions

DRUG

No Results Yet

NCT05152524 | ACTIVE_NOT_RECRUITING | NA

168 Participants

Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-03-25

Completion: 2025-12-31

Conditions

Ischemic Stroke Neovascularization

Interventions

DEVICE

No Results Yet

NCT05126277 | RECRUITING | PHASE3

462 Participants

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2022-07-14

Completion: 2027-06-22

Conditions

Lupus Nephritis

Interventions

DRUG

No Results Yet

NCT05124119 | COMPLETED

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2022-05-22

Completion: 2026-09-30

Conditions

Cervical Spondylosis Cervical Radiculopathy Cervical Myelopathy Cervical Disc Disease Cervical Stenosis Cervical Disc Herniation Cervical Spine Disease

No Results Yet