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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04091022 | COMPLETED | PHASE2
64 Participants

Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-01-18
Completion: 2025-12-11
Conditions
Non-melanoma Skin Cancer
Interventions
DRUG
No Results Yet
NCT04086485 | RECRUITING | PHASE1/PHASE2
56 Participants

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-10-03
Completion: 2027-07-01
Conditions
Gastroenteropancreatico Tumors Neuroendocrine Tumors Neuroendocrine Neoplasms
Interventions
DRUG DIAGNOSTIC_TEST
No Results Yet
NCT04085445 | COMPLETED
500 Participants

An "All-Comers" Study of the AgentTM MONORAILTM Paclitaxel-Coated PTCA Balloon Catheter Used in Real-World Clinical Practice in Chinese Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2019-11-13
Completion: 2022-08-31
Conditions
Chinese Patients Treated With Agent DCB
Interventions
DEVICE
No Results Yet
NCT04082962 | COMPLETED | PHASE1
10 Participants

Dexamethasone Implant for Retinal Detachment in Uveal Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2018-12-11
Completion: 2023-12-07
Conditions
Exudative Retinal Detachment and Uveal Melanoma
Interventions
DRUG
No Results Yet
NCT04067115 | COMPLETED | PHASE1/PHASE2
37 Participants

SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-01-05
Completion: 2025-04-24
Conditions
Ewing Sarcoma
Interventions
DRUG DIAGNOSTIC_TEST OTHER
No Results Yet
NCT04058652 | ACTIVE_NOT_RECRUITING | NA
20 Participants

Use of Transcutaneous Electrical Nerve Stimulation for Reducing Biologic Injection Site Pain(TENS Study)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-08-07
Completion: 2026-07-31
Conditions
Psoriasis
Interventions
DEVICE
No Results Yet
NCT04051502 | COMPLETED | EARLY_PHASE1
48 Participants

ICG-Enabled Mapping of Ovarian Sentinel Lymph Nodes: A Feasibility Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-08-05
Completion: 2025-12-08
Conditions
Ovarian Cancer Adnexal Mass
Interventions
DRUG
No Results Yet
NCT04050735 | COMPLETED | NA
76 Participants

Acute Neural and Immune Effects of Alcohol in People Living With HIV Infection

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-05-19
Completion: 2024-07-02
Conditions
HIV-1-infection Alcohol Drinking
Interventions
OTHER
Results Available
NCT04047641 | RECRUITING | PHASE1/PHASE2
80 Participants

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-10-22
Completion: 2027-12-31
Conditions
Acute Myeloid Leukemia Blasts 20 Percent or More of Bone Marrow Nucleated Cells High Risk Myelodysplastic Syndrome Recurrent Acute Biphenotypic Leukemia Recurrent Acute Myeloid Leukemia Recurrent High Risk Myelodysplastic Syndrome Refractory Acute Myeloid Leukemia Refractory High Risk Myelodysplastic Syndrome
Interventions
DRUG
No Results Yet
NCT04045093 | ACTIVE_NOT_RECRUITING | PHASE4
370 Participants

Dabigatran for Mitral Stenosis Atrial Fibrillation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-10-22
Completion: 2026-09-30
Conditions
Atrial Fibrillation Mitral Stenosis
Interventions
DRUG
No Results Yet
NCT04037527 | TERMINATED | PHASE1
9 Participants

Gemcitabine and Docetaxel With Radiation in Adults With Soft Tissue Sarcoma of the Extremities

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-08-18
Completion: 2024-06-18
Conditions
Soft Tissue Sarcoma
Interventions
DRUG RADIATION PROCEDURE OTHER
No Results Yet
NCT04021355 | COMPLETED | NA
53 Participants

Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-07-14
Completion: 2025-06-14
Conditions
Obesity Hypertension Circadian Dysregulation Salt; Excess
Interventions
OTHER
No Results Yet
NCT04016896 | COMPLETED | NA
151 Participants

Depression Prevention in Older Spousally-bereaved Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-10-20
Completion: 2025-01-17
Conditions
Depression
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04009343 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
182 Participants

Pharmacokinetics and Pharmacodynamics of the Gametocytocidal and Post-treatment Chemoprotective Effects of Antimalarials

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-06-19
Completion: 2020-08-24
Conditions
Uncomplicated Falciparum Malaria
Interventions
DRUG
No Results Yet
NCT04008368 | RECRUITING | PHASE1/PHASE2
32 Participants

Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-10-24
Completion: 2030-01-30
Conditions
Myeloid Chimerism
Interventions
DEVICE
No Results Yet
NCT03987555 | RECRUITING
20 Participants

Paclitaxel Therapeutic Drug Monitoring in Cancer Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2019-11-11
Completion: 2026-06-30
Conditions
Stage IVA Cervical Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVA Ovarian Cancer AJCC v8 Stage IVA Vulvar Cancer AJCC v8 Stage IVB Cervical Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8 Stage IVB Ovarian Cancer AJCC v8 Stage IVB Vulvar Cancer AJCC v8 Vulva Squamous Cell Carcinoma Solid Tumor, Adult Metastatic Nonsmall Cell Lung Cancer Anatomic Stage IV Breast Cancer AJCC v8 Metastatic Cervical Carcinoma Metastatic Ovarian Carcinoma Malignant Uterine Neoplasm Vulvar Cancer Invasive Breast Cancer Metastatic Breast Carcinoma Prognostic Stage IV Breast Cancer AJCC v8 Recurrent Breast Carcinoma Recurrent Cervical Carcinoma Recurrent Lung Non-Small Cell Carcinoma Recurrent Ovarian Carcinoma Recurrent Vulvar Carcinoma Stage IV Cervical Cancer AJCC v8 Stage IV Lung Cancer AJCC v8 Stage IV Vulvar Cancer AJCC v8 Stage IV Ovarian Cancer AJCC v8
Interventions
OTHER
No Results Yet
NCT03986034 | RECRUITING | PHASE2
75 Participants

Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-06-26
Completion: 2026-07-03
Conditions
Chronic Lymphocytic Leukemia
Interventions
DRUG
No Results Yet
NCT03959098 | ACTIVE_NOT_RECRUITING
120 Participants

Effectiveness and Safety of Korean Medicine Treatment for Cervical Disc Herniation

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2019-06-24
Completion: 2022-01-28
Conditions
Neck Pain Cervical Radiculopathy Intervertebral Disc Displacement
Interventions
DRUG PROCEDURE
No Results Yet
NCT03934372 | RECRUITING | PHASE1/PHASE2
70 Participants

Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-01-29
Completion: 2028-02-01
Conditions
Accelerated Phase Chronic Myeloid Leukemia Blast Phase Chronic Myeloid Leukemia Chronic Phase Chronic Myeloid Leukemia Acute Lymphoblastic Leukemia Acute Lymphocytic Leukemia Leukemia Lymphoma Solid Tumors Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
NCT03926052 | COMPLETED | PHASE3
61 Participants

Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Maintenance Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-08-07
Completion: 2024-11-18
Conditions
Binge-Eating Disorder Obesity
Interventions
DRUG
Results Available
NCT03881579 | ACTIVE_NOT_RECRUITING | NA
200 Participants

Supportive Care for Cognitively Impaired Patients and Families

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-12-18
Completion: 2024-11-30
Conditions
Dementia Primary Palliative Care Mild Cognitive Impairment
Interventions
BEHAVIORAL
No Results Yet
NCT03860792 | COMPLETED | NA
84 Participants

Therapeutic Diets in Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-10-15
Completion: 2025-05-23
Conditions
Alzheimer Disease
Interventions
BEHAVIORAL
No Results Yet
NCT03855800 | RECRUITING | NA
800 Participants

Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2018-05-11
Completion: 2030-12-30
Conditions
Pancreas Cyst
Interventions
DIAGNOSTIC_TEST PROCEDURE
No Results Yet
NCT03831386 | RECRUITING | NA
200 Participants

Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-01-31
Completion: 2026-12-31
Conditions
Pleural Effusion
Interventions
PROCEDURE
No Results Yet
NCT03803332 | RECRUITING | NA
208 Participants

A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-03-09
Completion: 2026-03-31
Conditions
PTSD
Interventions
BEHAVIORAL
No Results Yet
NCT03767348 | ACTIVE_NOT_RECRUITING | PHASE2
340 Participants

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-09-20
Completion: 2025-12-31
Conditions
Non-Small Cell Lung Cancer (NSCLC) Microsatellite Instability-High (MSI-H) Non-melanoma Skin Cancer (NMSC) Cutaneous Melanoma
Interventions
BIOLOGICAL
No Results Yet
NCT03758417 | TERMINATED | PHASE2
123 Participants

A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-01-23
Completion: 2025-07-10
Conditions
Multiple Myeloma
Interventions
BIOLOGICAL
No Results Yet
NCT03754790 | ACTIVE_NOT_RECRUITING | PHASE3
281 Participants

Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B, With or Without Inhibitory Antibodies to Factor VIII or IX

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-01-09
Completion: 2026-11-05
Conditions
Hemophilia
Interventions
DRUG
No Results Yet
NCT03749187 | ACTIVE_NOT_RECRUITING | PHASE1
78 Participants

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-04-03
Completion: 2026-06-30
Conditions
Glioblastoma IDH1 Gene Mutation IDH2 Gene Mutation Low Grade Glioma Malignant Glioma Recurrent Glioblastoma Recurrent WHO Grade II Glioma Recurrent WHO Grade III Glioma WHO Grade II Glioma WHO Grade III Glioma
Interventions
DRUG
No Results Yet
NCT03736889 | RECRUITING | PHASE2
200 Participants

Tislelizumab (Anti-Programmed Cell Death Protein-1 (PD-1) Antibody) in MSI-H or dMMR Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2018-09-19
Completion: 2026-11-30
Conditions
MSI-H/dMMR Solid Tumors
Interventions
DRUG
No Results Yet
NCT03701581 | RECRUITING | PHASE2/PHASE3
70 Participants

4-aminopyridine Treatment for Nerve Injury

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-06-05
Completion: 2027-07-31
Conditions
Nerve Injury Prostate Cancer
Interventions
DRUG OTHER
No Results Yet
NCT03696160 | COMPLETED | PHASE3
447 Participants

The Late Presenter Treatment Optimisation Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-03-05
Completion: 2024-06-17
Conditions
HIV/AIDS
Interventions
DRUG
Results Available
NCT03689400 | COMPLETED
19 Participants

Changes of Pain and Functional Parameters in Back Pain Patients Over Time

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2018-10-11
Completion: 2019-12-06
Conditions
Changes Over Time in Pain and Functional Parameters
Results Available
NCT03655678 | COMPLETED | PHASE2/PHASE3
59 Participants

A Safety and Efficacy Study Evaluating CTX001 in Participants With Transfusion-Dependent β-Thalassemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2018-09-14
Completion: 2025-11-13
Conditions
Beta-Thalassemia Thalassemia Genetic Diseases, Inborn Hematologic Diseases Hemoglobinopathies
Interventions
BIOLOGICAL
No Results Yet
NCT03638167 | COMPLETED | PHASE1
11 Participants

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-03-19
Completion: 2023-12-22
Conditions
Central Nervous System Tumor, Pediatric Glioma Ependymoma Medulloblastoma Germ Cell Tumor Atypical Teratoid/Rhabdoid Tumor Primitive Neuroectodermal Tumor Choroid Plexus Carcinoma Pineoblastoma
Interventions
BIOLOGICAL
No Results Yet
NCT03625648 | ACTIVE_NOT_RECRUITING | PHASE4
2376 Participants

Pentoxifylline in Diabetic Kidney Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-11-18
Completion: 2028-01-03
Conditions
Diabetic Kidney Disease
Interventions
DRUG
No Results Yet
NCT03623464 | ACTIVE_NOT_RECRUITING | NA
107 Participants

RCT of Mobile Apps & FitBit v. Usual Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-05-31
Completion: 2026-06-30
Conditions
Pancreatic Cancer Gastric Cancer Hepatic Cancer Colon Cancer Rectal Cancer Small Bowel Cancer
Interventions
OTHER
No Results Yet
NCT03622788 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
16 Participants

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-08-08
Completion: 2027-12-01
Conditions
Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Aplastic Anemia Bone Marrow Failure Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia, BCR-ABL1 Positive Follicular Lymphoma Hodgkin Lymphoma Mantle Cell Lymphoma Myelodysplastic Syndrome Myeloproliferative Neoplasm Non-Hodgkin Lymphoma Plasma Cell Myeloma
Interventions
BIOLOGICAL DRUG PROCEDURE RADIATION
No Results Yet
NCT03567889 | RECRUITING | PHASE3
186 Participants

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2018-09-20
Completion: 2027-12-31
Conditions
Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IIID
Interventions
DRUG PROCEDURE
No Results Yet
NCT03534193 | TERMINATED | NA
28 Participants

Effectiveness of Using Educational Modules Via Bedside Tablet in Newly Diagnosed Type 1 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-04-17
Completion: 2019-04-30
Conditions
Type 1 Diabetes Mellitus
Interventions
OTHER
Results Available
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