Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer

NCT ID: NCT04091022

Last Updated: 2025-12-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 64 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-01-18
• Study Completion Date: 2025-12-11

Brief Summary

This is a single institution, randomized, placebo-controlled, double-blind phase IIB trial of 1) topical diclofenac and topical DFMO, or 2) placebo in participants with a history of non melanoma skin cancer/ keratinocytic cancers.

Detailed Description

There will be two groups to the study. Individuals, aged 18 years or older, who have extensive actinic damage, at least 8 AKs and a history of at least one non-melanoma skin cancer, but are in otherwise general good health, will be given topical diclofenac and topical DFMO. They will be compared to individuals, aged 18 years or older, who have extensive actinic damage, but are in otherwise general good health, will be given placebo. All participants must be at increased risk of non-melanoma skin cancer as evidenced by a history of prior squamous or basal cell skin cancer, ongoing or history of actinic keratoses, and the presence, at baseline, of at least eight actinic keratoses on the face, neck, scalp and arms. Subjects will be randomized to:

1. topical diclofenac once daily and topical DFMO once daily

2. placebo for the topical diclofenac once daily and placebo for the topical DFMO once daily

Conditions

Non-melanoma Skin Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Diclofenac + DFMO

Participants in this arm will apply topical diclofenac to bilateral forearms once per day and topical DFMO to bilateral forearms once per day.

Group Type: ACTIVE_COMPARATOR

Solaraze and Vaniqa

Intervention Type: DRUG

Solaraze-topical diclofenac 3% and Vaniqa-topical eflornithine hydrochloride Cream, 13.9% applied to bilateral arms for a period of 9 months

Placebo + Placebo

Participants in this arm will apply placebo for topical diclofenac to bilateral forearms once per day and placebo for topical DFMO to bilateral forearms once per day.

Group Type: PLACEBO_COMPARATOR

Solaraze and Vaniqa

Intervention Type: DRUG

Solaraze-topical diclofenac 3% and Vaniqa-topical eflornithine hydrochloride Cream, 13.9% applied to bilateral arms for a period of 9 months

Interventions

Solaraze and Vaniqa

Solaraze-topical diclofenac 3% and Vaniqa-topical eflornithine hydrochloride Cream, 13.9% applied to bilateral arms for a period of 9 months

Intervention Type: DRUG

Other Intervention Names

Solaraze-topical diclofenac 3% and Vaniqa-topical eflornithine hydrochloride Cream, 13.9%

Eligibility Criteria

Inclusion Criteria

• Previous treatment for basal or squamous cell skin cancer stage 0-2 and current evidence of at least actinic keratosis on the upper extremities (upper arms, forearms and hands), neck, face or scalp.
• >18 years of age
• Ability to understand and willingness to sign a written informed consent document
• ECOG performance status 0-1
• Willing and able to participate for the full duration of the study
• Willing to abstain from:

• The application of topical medications including prescription and over the counter preparations (e.g., Topical preparations containing corticosteroids or vitamin A derivatives) to intended treatment areas for the duration of the study. Use of moisturizers/emollients and sunscreens on these areas is allowed.
• Chronic (defined as > 3 times/week for more than 2 consecutive weeks/year) NSAID and COX-2 inhibitor use (other than cardioprotective doses of aspirin < 100 mg po QD) for the duration of the study
• Normal organ and marrow function defined as laboratory values falling within the specified ranges for the following tests (performed within 365 days of registration)

Hematologic

• WBC >3,000/ul
• Hemoglobin > lower limit of normal
• Platelet count > 100,000/ul

Hepatic

• Total bilirubin < 1.5 X ULN
• AST (SGOT) < 1.5 X ULN
• ALT (SPGT) < 1.5 X ULN Renal
• Serum creatinine < 1.5 X ULN BUN < 1.5 X ULN

• Females of childbearing potential must:
• Have been using adequate contraception (abstinence, IUD, birth control pills or spermicidal gel with diaphragm or condom) since their last menses
• Have a documented negative urine pregnancy test prior to the first dose of study medication. (Females are not considered to be of childbearing potential if they are at least 1 year post-menopausal or have had a tubal ligation, bilateral oophorectomy or hysterectomy)
• The effects of DFMO and diclofenac on the developing fetus are unknown. Therefore, all females of childbearing potential and all men capable of fathering a child must agree to use adequate contraception (abstinence, IUD, birth control pills, or spermicidal gel with diaphragm or condom) for the duration of study participation.

Exclusion Criteria

Any of the following will render a participant ineligible to participate in this study:

• Aspirin >100 mg/day
• Chronic (> 3 times/week for more than a two week period) use of NSAIDs or COX-2 inhibitors
• Current use of topical steroids to intended treatment area (forearms)
• Cryotherapy to intended treatment area (forearms) within the preceding 3 months
• Use of oral or intravenous corticosteroids for more than 2 consecutive weeks

Any of the following in the 4 weeks prior to randomization:

• Major surgery for any indication
• Cytotoxic chemotherapy for any indication (including methotrexate for arthritis)
• Anti-cancer treatment of any type other than for a stage 0-2 non-melanoma skin cancer
• Hormonal therapy for cancer prevention ((treatment with finasteride/dutasteride for BPH does not render a participant ineligible.)
• Radiation therapy

Any of the following in the 6 month prior to randomization to the intended treatment area (forearms):

• Topical medications for the treatment of actinic keratosis or skin cancer (etretinate, 5-FU, imiquimod, ingenol)
• Laser resurfacing, dermabrasion, chemical peel and/or electrodissection ± curettage

• Any family history of Ornithine diaminotransferase deficiency in a first degree relative
• Any personal history of:
• Invasive cancer diagnosed or treated within the past 5 years. Participants who have been in remission for >5 years and have not required treatment in the past 5 years may be eligible if a study chair or principal investigator believes there is little to no risk of recurrence.
• Solid organ or bone marrow transplant
• Biopsy proven hepatic cirrhosis
• Keloid formation
• Photosensitivity disorder
• Hypersensitivity or adverse reactions to nonsteroidal anti-inflammatory agents
• Oral DFMO for > 1 month on a prior study
• Any disease that predisposes to NMSC
• An immunodeficiency disorder or the use of an immunosuppressive drug

• Concurrent use of the following medications or treatments:
• Systemic therapy with psoralens, immunotherapy, or retinoids.
• Cytotoxic chemotherapy for any reason (including methotrexate for arthritis)
• Topical or systemic immunosuppressive therapy

• Females who are pregnant or lactating. Should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should notify her study physician immediately.
• Uncontrolled concurrent illness including ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled symptomatic cardiac arrhythmia, psychiatric illness/social situations that would limit compliance with study requirements or other underlying serious medical condition which, in the investigator's opinion might preclude study participation.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

National Institutes of Health (NIH)

NIH

Sponsor Role: collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role: lead

Responsible Party

Craig Elmets

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Craug Elmets, MD

Role: PRINCIPAL_INVESTIGATOR

University of Alabama at Birmingham

Locations

Birmingham VA Medical Center

Birmingham, Alabama, United States

UAB Dermatology

Birmingham, Alabama, United States

Countries

United States

Other Identifiers

R01CA193885

Identifier Type: NIH

Identifier Source: secondary_id

View Link

300004144

Identifier Type: -

Identifier Source: org_study_id