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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06151236 | RECRUITING | PHASE2
20 Participants

Neoadjuvant Nivolumab and Relatlimab in Merkel Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-03-11
Completion: 2026-12-31
Conditions
Merkel Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT06140147 | RECRUITING | NA
1850 Participants

Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-11-27
Completion: 2027-12-31
Conditions
Septic Shock
Interventions
OTHER
No Results Yet
NCT06137742 | RECRUITING | PHASE1/PHASE2
90 Participants

A Study to Learn About the Study Medicine Called PF-07868489 in Healthy Adult People and in People With Pulmonary Arterial Hypertension

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-11-17
Completion: 2027-02-13
Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG
No Results Yet
NCT06136598 | ACTIVE_NOT_RECRUITING | PHASE1
14 Participants

A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-01-30
Completion: 2025-11-26
Conditions
Prostatic Neoplasms Metastatic Castration-Resistant Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06120608 | ACTIVE_NOT_RECRUITING | NA
50 Participants

Evidence for Potassium Restriction in Hemodialysis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2025-06-17
Completion: 2026-03-12
Conditions
Hyperkalemia, Diminished Renal Excretion
Interventions
BEHAVIORAL
No Results Yet
NCT06117852 | RECRUITING
5000 Participants

Chronic Kidney Disease Registry Platform Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-11-28
Completion: 2028-11-30
Conditions
Chronic Kidney Diseases
No Results Yet
NCT06116032 | RECRUITING
1500 Participants

Immune Profiling for Cancer Immunotherapy Response

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2022-10-03
Completion: 2027-01-01
Conditions
Cancer Tumor, Solid Hematologic Malignancy Blood Cancer
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT06109909 | RECRUITING | NA
36 Participants

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-01-01
Completion: 2026-11-30
Conditions
Mild Traumatic Brain Injury Photophobia
Interventions
DEVICE
No Results Yet
NCT06109844 | COMPLETED
13 Participants

FORCEREPAIR - A Wound Exudate Investigation

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2024-01-24
Completion: 2025-10-01
Conditions
Venous Leg Ulcer Wound Healing Non-healing Wound Cytokines
Interventions
OTHER
No Results Yet
NCT06108050 | RECRUITING | PHASE1
177 Participants

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-11-07
Completion: 2027-11-30
Conditions
Advanced Solid Tumor Metastatic Solid Tumor
Interventions
DRUG
No Results Yet
NCT06105723 | RECRUITING | NA
1000 Participants

An Effectiveness Evaluation for Pathway to Healthy Aging (Path-HA) Care on Health Status of Older Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-01-01
Completion: 2025-06-30
Conditions
Ageing Well
Interventions
BEHAVIORAL
No Results Yet
NCT06105632 | ACTIVE_NOT_RECRUITING | PHASE2
333 Participants

A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-01-09
Completion: 2026-03-31
Conditions
Advanced or Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT06105554 | RECRUITING | PHASE1/PHASE2
36 Participants

Phase I/II Open Label Study of Belumosudil Mesylate Alone, and in Combination With Dexamethasone, in Patients With Relapsed/Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-01-30
Completion: 2027-08-31
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT06098404 | RECRUITING
250 Participants

Correlates of CRCI and Gut Microbiome Dysbiosis; a Pilot Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2024-03-04
Completion: 2026-10-31
Conditions
Cancer
No Results Yet
NCT06096831 | ENROLLING_BY_INVITATION
240 Participants

Living With Stroke - Sustainable Utilization of Healthcare Services

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-11-15
Completion: 2026-03-31
Conditions
Stroke Cerebrovascular Disorders Cerebrovascular Accident Healthcare Utilization
No Results Yet
NCT06089746 | RECRUITING | NA
20 Participants

Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-11-15
Completion: 2026-09-30
Conditions
Lumbar Spinal Stenosis
Interventions
OTHER
No Results Yet
NCT06084910 | RECRUITING | NA
134 Participants

Self-Concept Reinforcement for Early School Readiness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-07-03
Completion: 2028-11-30
Conditions
Child Behavior Child Behavior Problem Child Behavior Disorders
Interventions
BEHAVIORAL
No Results Yet
NCT06071845 | RECRUITING | NA
400 Participants

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-10-16
Completion: 2026-06-01
Conditions
Barrett Esophagus Barretts Esophagus With Dysplasia Barrett's Esophagus Without Dysplasia Esophageal Adenocarcinoma
Interventions
DEVICE DIAGNOSTIC_TEST
No Results Yet
NCT06070857 | COMPLETED | PHASE1
81 Participants

Study of the Safety, Tolerability, and Pharmacokinetics of LV232 Capsules in Chinese Healthy Volunteers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-10-05
Completion: 2025-11-17
Conditions
Healthy Subjects
Interventions
DRUG
No Results Yet
NCT06054295 | RECRUITING
50 Participants

Somatic Mosaicism in Twins Discordant for Childhood Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2024-06-03
Completion: 2026-06-30
Conditions
Pediatric Central Nervous System Tumor Central Nervous System Tumor Discordant Twin Somatic Mutation
Interventions
OTHER
No Results Yet
NCT06039176 | RECRUITING
150 Participants

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-10-27
Completion: 2026-12-30
Conditions
LVAD Frailty GI Bleed Right Heart Failure Infections Hypertension Arrhythmias Stroke
Interventions
DEVICE
No Results Yet
NCT06037421 | RECRUITING
120 Participants

Metagenomic Analysis of Bacterial Microbiota in Breast Milk

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2025-09-08
Completion: 2028-12-31
Conditions
Bacteria in Breast Milk
Interventions
OTHER
No Results Yet
NCT06030089 | COMPLETED | NA
20 Participants

Plasma Dosage of Venetoclax in the Fup of AML Patients Treated With Aza + Ven

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-02-26
Completion: 2024-09-30
Conditions
Acute Myeloid Leukemia
Interventions
OTHER DRUG
No Results Yet
NCT06020508 | RECRUITING
36 Participants

Lumoptik BRIGHTPOINT Reflectometer Device for Lumbar Epidural Placement

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-09-12
Completion: 2026-07-31
Conditions
Lumbar Spine Surgery
Interventions
DEVICE
No Results Yet
NCT06001918 | RECRUITING | PHASE2/PHASE3
400 Participants

Nectero EAST System Clinical Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-10-25
Completion: 2028-03-31
Conditions
Abdominal Aortic Aneurysm
Interventions
DRUG
No Results Yet
NCT06001749 | RECRUITING | PHASE2
15 Participants

Psilocybin in Cancer Pain Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-09-23
Completion: 2026-07-01
Conditions
Opioid-Related Disorders Pain Management Pain Management and Care Advanced Cancer Advanced Cancers
Interventions
DRUG
No Results Yet
NCT05998447 | TERMINATED | PHASE2
10 Participants

GEN-001 Plus Pembrolizumab for Patients With Advanced Refractory Biliary Tract Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-09-18
Completion: 2024-11-26
Conditions
Biliary Tract Cancer
Interventions
DRUG
No Results Yet
NCT05987709 | COMPLETED | NA
2004 Participants

Study of Colorectal Cancer Screening Options

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-03-17
Completion: 2022-12-31
Conditions
Colon Cancer
Interventions
DIAGNOSTIC_TEST
Results Available
NCT05982795 | RECRUITING
30 Participants

Impact of Highly Effective Modulator Therapy on the Cystic Fibrosis Microbiome

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-11-08
Completion: 2026-12-01
Conditions
Cystic Fibrosis
Interventions
OTHER
No Results Yet
NCT05975268 | COMPLETED | PHASE3
747 Participants

A Clinical Study to Evaluate the Efficacy and Safety of Subcutaneous JS005 Injection in the Treatment of Adults With Moderate to Severe Chronic Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-08-28
Completion: 2025-08-20
Conditions
Moderate to Severe Chronic Plaque Psoriasis
Interventions
BIOLOGICAL
No Results Yet
NCT05963698 | RECRUITING | NA
4000 Participants

The Fourth Left Atrial Appendage Occlusion Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-11-30
Completion: 2029-09-01
Conditions
Atrial Fibrillation Stroke, Ischemic Systemic Embolism
Interventions
DEVICE
No Results Yet
NCT05962606 | RECRUITING | PHASE2
150 Participants

Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-02-02
Completion: 2026-05-30
Conditions
Community-acquired Pneumonia
Interventions
DRUG
No Results Yet
NCT05959005 | RECRUITING
125 Participants

Progression of Early Atrophic Lesions

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-10-20
Completion: 2028-06-30
Conditions
Age-Related Macular Degeneration
Interventions
OTHER
No Results Yet
NCT05952401 | COMPLETED | NA
59 Participants

Implementation Science to Reduce the Disparity in Tobacco Treatment Among Individuals With Serious Mental Illness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-02-02
Completion: 2024-12-13
Conditions
Smoking Smoking Cessation Tobacco Use Cessation
Interventions
BEHAVIORAL
Results Available
NCT05929833 | ENROLLING_BY_INVITATION | NA
500 Participants

BETTER (Brain Injury Education, Training, and Therapy to Enhance Recovery)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-01-26
Completion: 2027-01-31
Conditions
Traumatic Brain Injury
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT05922657 | RECRUITING
300 Participants

A Registry to Gather Real World Use Data on the Cerene® Cryotherapy Device

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-06-09
Completion: 2027-12-31
Conditions
Heavy Menstrual Bleeding Abnormal Uterine Bleeding Menorrhagia
Interventions
DEVICE
No Results Yet
NCT05902871 | RECRUITING | NA
45 Participants

Direct Selective Laser Trabeculoplasty in Ethnic Chinese Population

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-03-11
Completion: 2026-10-31
Conditions
Primary Open Angle Glaucoma Ocular Hypertension Normal Tension Glaucoma
Interventions
PROCEDURE DEVICE
No Results Yet
NCT05901974 | RECRUITING | PHASE2
23 Participants

Venetoclax Combined With Azactidine in the Treatment of ALAL

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-07-01
Completion: 2026-03-01
Conditions
Acute Leukemia of Ambiguous Lineage
Interventions
DRUG
No Results Yet
NCT05865457 | RECRUITING | NA
80 Participants

Efficacy and Safety of BUFY02 Versus TRB02 in the Treatment of Dry Eye Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2025-09-25
Completion: 2027-04-30
Conditions
Dry Eye Disease
Interventions
DEVICE
No Results Yet
NCT05865379 | RECRUITING | NA
80 Participants

Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2026-01-31
Completion: 2027-07-31
Conditions
Dry Eye Disease
Interventions
DEVICE
No Results Yet
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