Clinical Trials Updated in 2025

NCT04239573 | ACTIVE_NOT_RECRUITING | NA

4606 Participants

Comparing Two Methods to Follow Patients With Pancreatic Cysts

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-06-16

Completion: 2037-06-03

Conditions

Pancreatic Carcinoma

Interventions

PROCEDURE OTHER

No Results Yet

NCT04233866 | ACTIVE_NOT_RECRUITING | PHASE2

176 Participants

Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-08-26

Completion: 2026-06-30

Conditions

Metastatic Pancreatic Adenocarcinoma Stage IV Pancreatic Cancer AJCC v8

Interventions

DRUG OTHER

No Results Yet

NCT04188509 | TERMINATED | PHASE3

162 Participants

Open-Label Extension of Voxelotor

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-11-18

Completion: 2024-11-01

Conditions

Sickle Cell Disease

Interventions

DRUG

Results Available

NCT04181827 | ACTIVE_NOT_RECRUITING | PHASE3

419 Participants

A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-06-12

Completion: 2024-05-01

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT04166318 | ACTIVE_NOT_RECRUITING | PHASE2

252 Participants

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-01-02

Completion: 2029-12-31

Conditions

Anal Basaloid Carcinoma Anal Canal Cloacogenic Carcinoma Anal Canal Squamous Cell Carcinoma Anal Margin Squamous Cell Carcinoma Stage I Anal Cancer AJCC v8 Stage IIA Anal Cancer AJCC v8

Interventions

PROCEDURE DRUG OTHER RADIATION

No Results Yet

NCT04142320 | RECRUITING | NA

54 Participants

Closed-loop Optimized rTMS for Depression

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2021-06-01

Completion: 2025-08-30

Conditions

Major Depressive Disorder

Interventions

DEVICE

No Results Yet

NCT04139499 | COMPLETED

18 Participants

Use of High-resolution Manometry to Detect Upper Airway Obstruction During Sleep

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2019-01-16

Completion: 2021-05-05

Conditions

Obstructive Sleep Apnea

Interventions

PROCEDURE

No Results Yet

NCT04116671 | ACTIVE_NOT_RECRUITING | NA

5 Participants

Stimulation Combined With Powered Motorized Orthoses for Walking After Stroke

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-04-01

Completion: 2026-11-01

Conditions

Stroke Hemiparesis

Interventions

DEVICE

No Results Yet

NCT04115631 | ACTIVE_NOT_RECRUITING | PHASE2

360 Participants

A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-12-13

Completion: 2026-12-31

Conditions

Liver Lymphoma Mantle Cell Lymphoma

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT04115254 | RECRUITING | NA

397 Participants

Stereotactic Magnetic Resonance Guided Radiation Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-10-22

Completion: 2028-06-30

Conditions

Pancreas Cancer Lung Cancer Renal Cancer Adrenal Metastases Prostate Cancer Liver Metastases Oligoprogressive Nodal Metastases Metachronous Nodal Metastases Synchronous Nodal Metastases Mesothelioma Spine Metastases Brain Metastases Borderline Resectable Pancreatic Carcinoma

Interventions

RADIATION

No Results Yet

NCT04108208 | ACTIVE_NOT_RECRUITING | PHASE4

75 Participants

A Study of Apalutamide in Chinese Participants With Non Metastatic Castration Resistant Prostate Cancer (NM-CRPC)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-12-17

Completion: 2023-06-01

Conditions

Prostatic Neoplasms

Interventions

DRUG

Results Available

NCT04105868 | COMPLETED | NA

15 Participants

Adolescent Attention to Emotion Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-10-16

Completion: 2024-09-23

Conditions

Depression

Interventions

OTHER

Results Available

NCT04095663 | RECRUITING | NA

250 Participants

Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-10-01

Completion: 2027-02-01

Conditions

Diverticulitis

Interventions

PROCEDURE OTHER

No Results Yet

NCT04091048 | COMPLETED

1127 Participants

Optimize PRO Study

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2019-09-16

Completion: 2023-12-15

Conditions

Symptomatic Aortic Stenosis

Interventions

DEVICE

Results Available

NCT04064827 | TERMINATED | PHASE3

2 Participants

A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Participants With Stage 5 Chronic Kidney Disease (CKD)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-09-16

Completion: 2025-05-16

Conditions

Chronic Kidney Disease (CKD) Secondary Hyperparathyroidism (SHPT)

Interventions

DRUG

No Results Yet

NCT04024436 | TERMINATED | PHASE2

64 Participants

A Study of TAS-120 in Patients With Metastatic Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-01-28

Completion: 2023-05-31

Conditions

Metastatic Breast Cancer FGFR 1 High Amplification FGFR2 Amplification

Interventions

DRUG

Results Available

NCT03978442 | COMPLETED | PHASE4

120 Participants

CPT-SMART for Treatment of PTSD and Cigarette Smoking

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-11-07

Completion: 2025-10-08

Conditions

Smoking Stress Disorders, Post-Traumatic

Interventions

BEHAVIORAL DRUG

No Results Yet

NCT03937635 | RECRUITING | PHASE3

288 Participants

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-09-16

Completion: 2029-12-31

Conditions

Smoldering Plasma Cell Myeloma

Interventions

BIOLOGICAL DRUG OTHER

No Results Yet

NCT03935750 | ACTIVE_NOT_RECRUITING | NA

1236 Participants

STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-07-28

Completion: 2026-02-28

Conditions

Anterior Cruciate Ligament Injury Anterior Cruciate Ligament Reconstruction Joint Instability

Interventions

PROCEDURE

No Results Yet

NCT03901963 | ACTIVE_NOT_RECRUITING | PHASE3

200 Participants

A Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Participants With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-04-26

Completion: 2024-04-04

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT03899155 | RECRUITING | PHASE2

1500 Participants

Pan Tumor Rollover Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-08-09

Completion: 2029-08-25

Conditions

Cancer

Interventions

DRUG

No Results Yet

NCT03818763 | ACTIVE_NOT_RECRUITING | PHASE1

5 Participants

Gene Therapy Trial for Platelet Derived Factor VIII Production in Hemophilia A

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-04-29

Completion: 2026-03-31

Conditions

Hemophilia A

Interventions

BIOLOGICAL

No Results Yet

NCT03804255 | WITHDRAWN

0 Participants

Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2019-01-08

Completion: 2020-05-29

Conditions

Breast Carcinoma Colorectal Carcinoma Community Practice Lung Carcinoma Melanoma Solid Neoplasm

Interventions

OTHER

No Results Yet

NCT03797183 | RECRUITING

90 Participants

Genesis Electrical Impedance Tomography (EIT): A Preliminary Study

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2019-05-03

Completion: 2026-11-30

Conditions

Premature Infant Chronic Respiratory Disease Neuromuscular Diseases Healthy Bronchopulmonary Dysplasia Pulmonary Vein Stenoses

No Results Yet

NCT03787290 | SUSPENDED | PHASE2

35 Participants

Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2026-12-01

Completion: 2028-12-01

Conditions

Major Depressive Disorder

Interventions

DRUG DEVICE

No Results Yet

NCT03750513 | RECRUITING | PHASE1

48 Participants

LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-04-01

Completion: 2027-12-31

Conditions

Anaplastic Ependymoma Ependymoma

Interventions

RADIATION OTHER

No Results Yet

NCT03748641 | ACTIVE_NOT_RECRUITING | PHASE3

765 Participants

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-01-25

Completion: 2021-10-08

Conditions

Castration-Resistant Prostatic Cancer

Interventions

DRUG

Results Available

NCT03718325 | TERMINATED | NA

12 Participants

Burst Spinal Cord Stimulation (Burst-SCS) Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-03-12

Completion: 2020-03-10

Conditions

Pain, Chronic Failed Back Surgery Syndrome

Interventions

DEVICE

Results Available

NCT03706430 | TERMINATED

63 Participants

Validation of RPVi as a Parameter to Predict Fluid Responsiveness

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2018-09-24

Completion: 2021-10-20

Conditions

Surgery Anesthesia

Interventions

DEVICE

Results Available

NCT03697148 | ACTIVE_NOT_RECRUITING | NA

852 Participants

Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-02-11

Completion: 2025-12-31

Conditions

Prostate Carcinoma

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT03674138 | COMPLETED | NA

99 Participants

Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2018-09-12

Completion: 2021-09-03

Conditions

Depression Anxiety Generalized Anxiety Disorder Depressive Disorder Major Depressive Disorder Cancer

Interventions

DIAGNOSTIC_TEST OTHER

No Results Yet

NCT03670355 | COMPLETED | PHASE1

49 Participants

Pharmacokinetic and Safety Study of a 90 Day Intravaginal Ring Containing Tenofovir

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-01-02

Completion: 2019-09-25

Conditions

HIV Infections

Interventions

DRUG

Results Available

NCT03633708 | RECRUITING | PHASE3

56 Participants

A Study of Etelcalcetide in Pediatric Subjects With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-04-29

Completion: 2029-01-31

Conditions

Secondary Hyperparathyroidism Chronic Kidney Disease

Interventions

DRUG

No Results Yet

NCT03623958 | RECRUITING | NA

200 Participants

Image Guided VATS vs. VATS Resection

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2018-09-11

Completion: 2027-07-31

Conditions

Lung Cancer

Interventions

DEVICE PROCEDURE

No Results Yet

NCT03581292 | ACTIVE_NOT_RECRUITING | PHASE2

38 Participants

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2018-11-06

Completion: 2023-03-31

Conditions

Anaplastic Astrocytoma Glioblastoma Malignant Glioma

Interventions

RADIATION DRUG

Results Available

NCT03550391 | RECRUITING | PHASE3

206 Participants

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2018-11-22

Completion: 2027-06-30

Conditions

Brain Metastases

Interventions

DRUG RADIATION PROCEDURE

No Results Yet

NCT03525951 | COMPLETED | NA

156 Participants

Parent-Level Predictors of Early Language Interaction Quality and Intervention Outcomes

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2021-03-22

Completion: 2025-09-18

Conditions

Language Development Disorders Autism Spectrum Disorder

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT03517436 | ACTIVE_NOT_RECRUITING | NA

101 Participants

ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2018-09-18

Completion: 2020-10-02

Conditions

Aortic Valve Stenosis

Interventions

DEVICE

Results Available

NCT03516279 | ACTIVE_NOT_RECRUITING | PHASE2

40 Participants

Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-06-26

Completion: 2028-08-31

Conditions

Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Minimal Residual Disease

Interventions

DRUG OTHER BIOLOGICAL

No Results Yet

NCT03504644 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

74 Participants

Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2018-08-03

Completion: 2025-12-31

Conditions

Recurrent Adult Lymphoblastic Lymphoma Recurrent B Acute Lymphoblastic Leukemia Recurrent B Lymphoblastic Lymphoma Recurrent T Acute Lymphoblastic Leukemia Recurrent T Lymphoblastic Lymphoma Refractory B Acute Lymphoblastic Leukemia Refractory B Lymphoblastic Lymphoma Refractory T Acute Lymphoblastic Leukemia Refractory T Lymphoblastic Lymphoma

Interventions

PROCEDURE DRUG

No Results Yet