Genesis Electrical Impedance Tomography (EIT): A Preliminary Study
NCT ID: NCT03797183
Last Updated: 2025-11-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
90 participants
OBSERVATIONAL
2019-05-03
2026-11-30
Brief Summary
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Detailed Description
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Researchers will use EIT to determine changes in regional ventilation with pulmonary interventions including airway clearance and invasive and noninvasive ventilation in a pediatric respiratory disease population.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Premature Infants
Premature infants \>1 month of age currently hospitalized with bronchopulmonary dysplasia (BPD) without acute respiratory infection
No interventions assigned to this group
Chronic Respiratory Disease
Participants ages \>1 month-21 years with chronic respiratory disease due to underlying neuromuscular disease
No interventions assigned to this group
Neuromuscular Disease
Participants ages 21-40 years with confirmed neuromuscular disease with an echo completed within the preceding 12 months of study participation of Duchenne muscular dystrophy (DMD) or other diagnoses associated with mild cardiomyopathy
No interventions assigned to this group
Healthy Controls
Age and height matched healthy controls
No interventions assigned to this group
V/Q Scan validation
Adults or children who are having or have recently had a V/Q scan
No interventions assigned to this group
Premature Infants (Longitudinal Cohort)
Premature infants ages 2 weeks to 1 year with diagnosed or suspected bronchopulmonary dysplasia
No interventions assigned to this group
Pulmonary Vein/Artery Stenosis
Children age 2 months to 18 years, who will be undergoing cardiac catheterization for pulmonary vein stenosis, pulmonary hypertension and/or pulmonary artery stenosis
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Premature infants with current age \>2 weeks with a confirmed diagnosis of BPD based on NIH criteria
* Or Chronic respiratory disease due to underlying neuromuscular disease
* Or confirmed neuromuscular disease with an echo completed within the preceding 12 months of study participation of DMD or other diagnoses associated with mild cardiomyopathy.
* have had a VQ scan
* will be undergoing cardiac catherization for for pulmonary vein stenosis, pulmonary hypertension and/or pulmonary artery stenosis
* Or healthy controls
Exclusion Criteria
* Congenital diaphragmatic hernia
* Severe congenital heart disease
* Significant genetic abnoralities
* Anything that interferes with lead placement on the chest wall
* Unwilling/refusal to sign consent
* Pregnant or lactating
* Pacemaker of other surgical implant and spinal implant (causes noise in the data)
* Moderate to severe cardiomyopathy
* Patients with temporary cognitive disability due to illness
14 Days
40 Years
ALL
Yes
Sponsors
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University of Colorado, Denver
OTHER
Responsible Party
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Locations
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Children's Hospital Colorado
Aurora, Colorado, United States
Countries
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Central Contacts
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Facility Contacts
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Emily DeBoer, MD
Role: primary
Allison Keck
Role: backup
Other Identifiers
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18-1843
Identifier Type: -
Identifier Source: org_study_id