Relationship Between EIT and Respiratory Status in Very Preterm Infants

NCT ID: NCT06609135

Last Updated: 2025-10-09

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-04

Study Completion Date

2024-08-31

Brief Summary

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Electrical Impedance Tomography (EIT) is a non-invasive imaging technique that can measure lung function in real time. This study will follow premature infants to see if EIT can help predict which infants will be successful in weaning off respiratory support by 32-33 weeks gestational age. If successful, EIT could be used to develop new guidelines for respiratory support in premature infants.

Detailed Description

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Conditions

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Chronic Lung Disease of Prematurity Bronchopulmonary Dysplasia Premature Lungs

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Electrical Impedance Tomography (EIT) and CO2 monitor

Participating infants will have the EIT belt placed at a minimum of twice per week throughout the NICU stay. A respiratory therapist or physician will place the EIT belt at the end of a feed and remove it at the next feed. A transcutaneous CO2 monitor will be placed concurrently.

Group Type EXPERIMENTAL

Sentec LuMon Device (EIT system)

Intervention Type DEVICE

Sentec EIT belts will be placed on infants up to once daily from consent through NICU discharge.

Sentec Digital Monitoring System (transcutaneous CO2 monitor)

Intervention Type DEVICE

Sentec transcutaneous CO2 monitors will be placed on infants concurrently with EIT belts.

Interventions

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Sentec LuMon Device (EIT system)

Sentec EIT belts will be placed on infants up to once daily from consent through NICU discharge.

Intervention Type DEVICE

Sentec Digital Monitoring System (transcutaneous CO2 monitor)

Sentec transcutaneous CO2 monitors will be placed on infants concurrently with EIT belts.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Infants admitted to the University of Massachusetts Memorial Medical Center (UMMMC) Neonatal Intensive Care Unit (NICU)
* Born between 25+0- and 29+6-weeks of gestation

Exclusion Criteria

* Infants with major congenital anomalies
* Infants with severe hemodynamic instability
Minimum Eligible Age

5 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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SenTec AG, Ringstrasse 39, CH-4106 Therwil

UNKNOWN

Sponsor Role collaborator

Lawrence Rhein

OTHER

Sponsor Role lead

Responsible Party

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Lawrence Rhein

Chair, Department of Pediatrics

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lawrence Rhein, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

UMASS Chan Medical School

Locations

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UMASS Memorial Medical Center

Worcester, Massachusetts, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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STUDY00001180

Identifier Type: -

Identifier Source: org_study_id

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