Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
NCT ID: NCT06684119
Last Updated: 2025-02-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2024-12-10
2027-07-01
Brief Summary
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Identify the difference between the optimal PEEP recommended by EIT metrics and the current guideline recommended approach to identifying optimal PEEP in PARDS. There will be a statistically significant difference in the recommended optimal PEEP identified using the EIT PEEP titration tool and that of the PEEP/FiO2 grid recommendations.
Determine the difference in physiologic metrics between EIT optimal PEEP and the PEEP/FiO2 recommended PEEP.
Participants will undergoing EIT monitoring while being subjected to PEEP titration protocol.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Electrical Impedance Tomography positive end-expiratory pressure
Patients will be monitored using Electrical Impedance Tomography and the positive end-expiratory pressure titration tool as their positive end-expiratory pressure is adjusted according to a step wise positive end-expiratory pressure titration protocol.
Electrical Impedance Tomography positive end-expiratory pressure titration
A PEEP titration will occur for the patient with the PEEP increased by 2 cm H2O every 2 minutes until a maximum PEEP of 20 or three steps (+ 6 cm H2O) above the set clinical PEEP. The PEEP will then be decreased by 2 cmH2O every 2 minutes until a minimum PEEP of 6 cmH2O or three steps (- 6 cm H2O) below their clinical PEEP.
Interventions
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Electrical Impedance Tomography positive end-expiratory pressure titration
A PEEP titration will occur for the patient with the PEEP increased by 2 cm H2O every 2 minutes until a maximum PEEP of 20 or three steps (+ 6 cm H2O) above the set clinical PEEP. The PEEP will then be decreased by 2 cmH2O every 2 minutes until a minimum PEEP of 6 cmH2O or three steps (- 6 cm H2O) below their clinical PEEP.
Eligibility Criteria
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Inclusion Criteria
* is on invasive mechanical ventilation
* is not spontaneously breathing
* meets PARDS criteria
Exclusion Criteria
* Hemodynamic instability
* Contraindications to hypercapnia
* patients with uncuffed endotracheal or tracheostomy tubes
* diagnosis of pneumothorax or bronchopleural fistula
* non-conventional ventilation
* any patient on extra-corporeal membrane oxygenation (ECMO) support
* less than 1 week post-operatively from cardiac surgery
* the following cardiac diagnoses: Glenn or Fontan physiology, significant right to left shunt
* Corrected Gestational Age \< 37 weeks
* pregnancy
0 Years
18 Years
ALL
No
Sponsors
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Children's Hospital Los Angeles
OTHER
Responsible Party
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Anoopindar Bhalla
Medical Staff/USC Faculty
Principal Investigators
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Anoopindar Bhalla, MD
Role: STUDY_DIRECTOR
Children's Hospital Los Angeles
Locations
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Children's Hospital Los Angeles
Los Angeles, California, United States
Countries
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Central Contacts
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Facility Contacts
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Hayden Leeds
Role: primary
Other Identifiers
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CHLA-24-00295
Identifier Type: -
Identifier Source: org_study_id
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