Implant Rehabilitations in a Hospital Setting

NCT ID: NCT07332195

Last Updated: 2026-02-06

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2026-02-01
• Study Completion Date: 2030-12-01

Brief Summary

Dental implants are considered a predictable rehabilitation option for tooth extraction or missing teeth. The use of dental implants has evolved into a viable prosthetic alternative to conventional tooth-supported fixed prostheses or removable dentures, with advantages in terms of patient satisfaction and quality of life. Long-term studies have reported excellent success and survival rates for implants used in prosthetic rehabilitation. Benefits in terms of patient satisfaction and preservation of adjacent tooth structure are among the advantages of implant-supported restorations over prosthetic alternatives. However, dental implants can be subject to mechanical and biological complications. After the first year of function, marginal bone loss is minimal around most oral implants. Nevertheless, marginal bone loss or the onset of bacterial-related biological complications, such as mucositis and peri-implantitis, can occur. Despite the growing number of publications in the field of implant rehabilitation, to date only a few studies have investigated the outcomes of implant rehabilitation in a hospital setting characterized by patients with concomitant or previous systemic therapies and pathologies. The objective of this study is to evaluate the success of implant therapy, peri-implant marginal bone resorption (MBL), clinical parameters of peri-implant health, aesthetic parameters of rehabilitation, and patient-reported treatment outcomes in a sample of patients treated in a hospital setting.

Conditions

Patients Requiring an Implant-supported Rehabilitation; Edentulous Patients Requiring an Implant-supported Rehabilitation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Implant-supported rehabilitation

Patients aged \>18 years who require implant-supported rehabilitation

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients requiring implant surgery for edentulous rehabilitation;
• Age > 18;
• Achievement of FMPS and FMBS ≤ 15%;
• Signed written informed consent to participate in the study.

Exclusion Criteria

• Uncontrolled diabetes or hypertension;
• Uncontrolled periodontal disease;
• Inability to perform consistent and continuous follow-up;
• Pregnancy or breastfeeding;
• Inability to provide written informed consent.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Carlo Lajolo

Role: PRINCIPAL_INVESTIGATOR

Fondazione Policlinico Universitario A. Gemelli, IRCCS

Central Contacts

Carlo Lajolo, MD, DDS

Role: CONTACT

carlo.lajolo@unicatt.it

+390630154286

References

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Reference Type: BACKGROUND

PMID: 19885446 (View on PubMed)

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Reference Type: BACKGROUND

PMID: 8270307 (View on PubMed)

Nir-Hadar O, Palmer M, Soskolne WA. Delayed immediate implants: alveolar bone changes during the healing period. Clin Oral Implants Res. 1998 Feb;9(1):26-33. doi: 10.1034/j.1600-0501.1998.090104.x.

Reference Type: BACKGROUND

PMID: 9590942 (View on PubMed)

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Reference Type: BACKGROUND

PMID: 6809663 (View on PubMed)

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Reference Type: BACKGROUND

den Hartog L, Slater JJ, Vissink A, Meijer HJ, Raghoebar GM. Treatment outcome of immediate, early and conventional single-tooth implants in the aesthetic zone: a systematic review to survival, bone level, soft-tissue, aesthetics and patient satisfaction. J Clin Periodontol. 2008 Dec;35(12):1073-86. doi: 10.1111/j.1600-051X.2008.01330.x.

Reference Type: BACKGROUND

PMID: 19040585 (View on PubMed)

Siadat H, Alikhasi M, Beyabanaki E. Interim Prosthesis Options for Dental Implants. J Prosthodont. 2017 Jun;26(4):331-338. doi: 10.1111/jopr.12421. Epub 2016 Jan 24.

Reference Type: BACKGROUND

PMID: 26805651 (View on PubMed)

Other Identifiers

ID 7698

Identifier Type: -

Identifier Source: org_study_id