Clinical Performance of the I-arch System During the Initial Stage of Orthodontic Treatment

NCT ID: NCT07264127

Last Updated: 2025-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-31

Study Completion Date

2026-09-30

Brief Summary

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The goal of this clinical trial is to learn if the I-arch system works to align the moderately misaligned teeth in patients seeking orthodontic treatment. it aims to answer the following questions:

* Does I-arch system increase the rate of teeth alignment?
* Does I-arch system produce significant changes in arch width and incisors inclination?
* Does I-arch system decrease the intensity of patient-reported pain and root resorption? Researchers will compare the effectiveness of the I-arch and MBT arch wire system.

Detailed Description

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This study will be a multicenter non-stratified prospective randomized clinical trial designed as a blinded, parallel group trial with equal randomization (1:1 allocation ratio). It will be conducted at multiple orthodontic centers. Initially, the eligibility of the patients to participate in this study will be evaluated by the investigator. Verbal information about the nature of study will be supplied for those who will satisfy the inclusion criteria to obtain their preliminary approval. Then the patient information sheet and consent form will be given to the patients to read carefully at home to decide whether they will participate in the study at the following visit. Patient assent/parental consent will be taken for participants below 18 years. If the patients have any queries regarding the study, the investigator should resolve it on the following visit.

Orthodontic treatment will be conducted using a straight wire appliance. MBT prescription brackets with 0.018-inch slot (Microfit™, SIA Orthodontic Manufacturer, Italy) will be used. With the aid of a height gauge, standardized bracket placement will be achieved. The technique will begin with a 10-second prophylactic procedure to clean and polish the teeth surfaces with pumice and a rubber cup using a slow-speed handpiece. Then, teeth will be rinsed with water and dried with oil-free air spray for 30 seconds. For the purpose of standardization, bonding procedure will be as followed:

* The enamel surface will be etched with 37% phosphoric acid gel for 30 seconds.
* The acid etchant will be rinsed off with water spray thoroughly.
* The tooth surface will be dried by air spray until the white frosty appearance of the etched surface is seen.
* A thin layer of Light Bond™ Sealant (Reliance®, Itasca, USA) will be applied on the etched enamel surface for one minute, then air will be applied for 5 seconds.
* Brackets and tubes will be bonded using Light Bond™ light cure orthodontic adhesive (Reliance®, Itasca, USA) which applied on their bases and light-cured above interproximal contacts at a distance of 2-3 mm (5 seconds mesially and 5 seconds distally for brackets and 10 seconds mesially and 10 seconds occlusally for molar tubes).

Arch wire sequence for each group will be as follows:

1. I-arch system group (I-arch™ Orthodontic System, SIA Orthodontic Manufacturer, Italy. (

• 0.016×0.014-inch copper nickel titanium.
2. MBT arch wire system group (Thermal NiTi™, SIA Orthodontic Manufacturer, Italy)

* 0.014-inch heat-activated nickel titanium.
* 0.016-inch heat-activated nickel titanium. A standardized protocol will be followed during the treatment for all the participants. At the day of bonding, 0.016×0.014 copper nickel titanium arch wire will be placed for the I-arch group and religated every four weeks. While, for the MBT group, 0.014-inch heat-activated nickel titanium arch wire will be placed at the day of bonding, then after 8 weeks it will be replaced by the 0.016-inch heat-activated nickel titanium arch wire for another 8 weeks (both will be religated every four weeks). Elastomeric modules will be used for ligating the wire to the brackets. If any bracket debonding occurs throughout the course of the treatment, it should be bonded again during 24 hours. Otherwise, the participant will be excluded from the trial. Since this study will be performed during the initial phase of treatment, no deviation from the protocol of treatment will be accepted (such as adding additional arch wire in the sequence or using power chain). Digital scan for the maxillary and mandibular arches will be taken pre-treatment and after 4, 8, 12 and 16 weeks, and a digital model will be obtained which will be used to measure Little's irregularity index, the intercanine and intermolar widths. Lateral cephalometric radiograph and periapical radiographs (for the maxillary and mandibular central incisors) will be taken pre-treatment and after 16 weeks. Lateral cephalometric radiographs will be used to measure the inclination of the maxillary and mandibular incisors. While the periapical radiographs will be used to assess the root resorption of the maxillary and mandibular central incisors. The participants will be supplied with a visual analog scale (0-10) to record their pain perception during the first seven days following the first wire placement. At the end of the trial, the treatment will continue as prescribed.

Conditions

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Effectiveness of I-arch System

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Arm 1: I-arch system

Intervention: Use of 0.016×0.014-inch copper nickel titanium arch wire during the alignment stage.

Group Type EXPERIMENTAL

The use of 0.016×0.014 copper nickel titanium arch wire during the alignment stage.

Intervention Type DEVICE

Teeth alignment using an initial arch wire with a rectangular switched cross-section since the beginning of the treatment.

Arm 2: MBT arch wire system

Intervention: Use of 0.014- then 0.016-inch heat-activated nickel titanium arch wire during the alignment stage.

Group Type ACTIVE_COMPARATOR

Use of 0.014- then 0.016-inch heat-activated nickel titanium arch wire during the alignment stage.

Intervention Type DEVICE

Teeth alignment using initial arch wires with round cross sections.

Interventions

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The use of 0.016×0.014 copper nickel titanium arch wire during the alignment stage.

Teeth alignment using an initial arch wire with a rectangular switched cross-section since the beginning of the treatment.

Intervention Type DEVICE

Use of 0.014- then 0.016-inch heat-activated nickel titanium arch wire during the alignment stage.

Teeth alignment using initial arch wires with round cross sections.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Moderate crowding of mandibular anterior teeth (3-6 mm) according to Little's irregularity index (LII) in patients with age of 12 years or older.
2. Full complement of permanent dentition should be present, except for the third molars.
3. Brackets should be placed on maxillary and mandibular anterior teeth without any interference by the existing overbite and overjet.
4. The maxillary and mandibular incisors should not be previously subjected to trauma or root resorption.

Exclusion Criteria

1. Patients with history of previous orthodontic treatment.
2. Severe maxillary and mandibular anterior crowding which is greater than 6 mm (LII).
3. Presence of teeth that are severely misaligned out of the dental arch and cannot be engaged with the aligning arch wire.
4. Prescence of periodontally compromised teeth and previous loss of attachment.
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Baghdad

OTHER

Sponsor Role collaborator

Tabark H. Omran

OTHER

Sponsor Role lead

Responsible Party

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Tabark H. Omran

Principal investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Yassir Yassir, PhD

Role: STUDY_DIRECTOR

College of dentistry/ Baghdad university

Central Contacts

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Tabark H. Omran

Role: CONTACT

B.D.S ext. +9647711387246

Prof. dr. Yassir A. Yassir, PhD

Role: CONTACT

Other Identifiers

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ORTHO-UOB-2025

Identifier Type: -

Identifier Source: org_study_id

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