Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE4

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-20

Study Completion Date

2026-01-25

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020).

There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office.

Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office.

Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio.

Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Articaine vs Lidocaine for Pediatric Dental Procedures

NCT03318952

Anesthesia, Dental Pain, Postoperative

WITHDRAWN PHASE4

Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits

NCT01912755

Irreversible Pulpitis Pain

COMPLETED PHASE4

How Successful is Supplemental Intraseptal Anaesthesia in Patients With Mandibular Teeth Extraction or Irreversible Pulpitis

NCT03880409

Overcoming the Failure of Anesthesia in the Mandibular Teeth

COMPLETED PHASE1

Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar

NCT01567839

Anesthetic Effectiveness

COMPLETED PHASE4

Usefulness of Lidocaine in Oral and Maxillofacial Surgeries Under General Anesthesia for Pain Control After Operation

NCT03479320

Pain, Postoperative

COMPLETED PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dental Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized, double-blind, parallel-group experimental study. Control group: 2% lidocaine; experimental group: 4% articaine. The RCT will be conducted in accordance with the Consolidated Standards of Reporting Trials (CONSORT 2010) guidelines.

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Blinding will be performed by the study investigators. The RCT is a double-blind trial, where neither the operator nor the patient knows the result of the anesthesia being administered.

The preparation of the intervention will be carried out by dividing the anesthetic cartridges, 50 for the control group (lidocaine) and 50 for the experimental group (articaine).

Since both articaine and lidocaine are from the same manufacturer, they have the same color silicone plunger, so we will simply cover the logo with an adhesive sticker and store them in a box. To distinguish which of the tubes corresponds to articaine or lidocaine once they have the sticker, they will be assigned the same numbers that will be used to randomize each patient (1 and 2 interleaved), with No. 1 being articaine and No. 2 being lidocaine. These will be in their respective boxes with their numbering.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Lidocaine

Participant in this group will receive lidocaine as a local anesthetic during dental procedures.

Group Type ACTIVE_COMPARATOR

lidocaine + epinephrine 1:100,000

Intervention Type DRUG

Administration of lidocaine as a local anesthetic during dental extraction.

Articaine

Participant in this group will receive articaine as a local anesthetic during dental procedures.

Group Type EXPERIMENTAL

Articaine 4% with epinephrine 1:100,000

Intervention Type DRUG

Administration of articaine as a local anesthetic during dental extraction.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

lidocaine + epinephrine 1:100,000

Administration of lidocaine as a local anesthetic during dental extraction.

Intervention Type DRUG

Articaine 4% with epinephrine 1:100,000

Administration of articaine as a local anesthetic during dental extraction.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques.
* Patients without systemic diseases (ASA I)
* Patients with controlled systemic disease (ASA II)
* Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)
* Patients with stable periodontal condition, without active infection that could affect the diffusion of the anesthetic.
* Patients with the ability to understand the procedure and provide informed consent.

Exclusion Criteria

* Patients with uncontrolled systemic diseases ASA III and pregnant patients.
* Patients requiring trunk techniques (Gow gates, Spix, Carrea)
* Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants)
* Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety.
* Patients with anatomical abnormalities in the orofacial region that interfere with the administration or action of anesthesia.
* Patients with a history of recent substance abuse.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes