Comparative Evaluation of Pulpal Anaesthetic Efficacy of Different Anaesthetic Solutions for Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis

NCT ID: NCT05239078

Last Updated: 2022-02-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 120 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-03-01
• Study Completion Date: 2017-02-28

Brief Summary

Pulpal and periapical inflammation and infection can cause tissue pH in the affected region to be lowered which results in less penetration of anesthetic solution in the nerve membrane and hence delays the onset of anesthesia. So, the purpose of this study was to compare the pulpal anesthetic efficacy of lidocaine, articaine, mepivacaine for inferior alveolar nerve block (IANB) in patients with irreversible pulpitis (IP). One hundred and twenty adult patients with IP concerning mandibular molars randomly received IANB with either of the three solutions: 2% lidocaine with epinephrine; 4% articaine with epinephrine; 3% plain mepivacaine. Pain during the endodontic treatment was assessed using a visual analog scale (Heft-Parker VAS). Endodontic treatment was initiated. Success was defined as no or mild pain (pain score≤54mm on Hp VAS) during access preparation and root canal instrumentation. The anesthetic success rates were analyzed with the chi-square test.

Conditions

Pulpitis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Inferior Alveolar nerve block with 2% lidocaine with epinephrine

An inferior alveolar nerve block was given with 2% lidocaine with epinephrine

Group Type: ACTIVE_COMPARATOR

local anaesthetic injection

Intervention Type: DRUG

Inferior alveolar nerve block

Inferior Alveolar nerve block with 4% articaine with epinephrine

An inferior alveolar nerve block was given with 4% articaine with epinephrine

Group Type: EXPERIMENTAL

local anaesthetic injection

Intervention Type: DRUG

Inferior alveolar nerve block

Inferior Alveolar nerve block with 3% plain mepivacaine

An inferior alveolar nerve block was given with 3% plain mepivacaine

Group Type: EXPERIMENTAL

local anaesthetic injection

Intervention Type: DRUG

Inferior alveolar nerve block

Interventions

local anaesthetic injection

Inferior alveolar nerve block

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• active pain in a mandibular molar
• prolonged response to cold testing with an ice stick and an electric pulp tester
• absence of any periapical radiolucency on radiographs, except for a widened periodontal ligament
• vital coronal pulp on access opening and ability to understand the use of pain scales

Exclusion Criteria

• known allergy, sensitivity, or contraindications to any opioid or nonopioid analgesic including aspirin or NSAIDs
• history of active peptic ulcer within the preceding 12 months
• history of bleeding problems or anticoagulant use within the last month
• patients who were pregnant or breast-feeding
• a history of known or suspected drug abuse
• patients who had taken NSAIDs within 12 h before administration of the study drugs

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

SGT DENTAL COLLEGE

UNKNOWN

Sponsor Role: collaborator

Dr. Vivek Aggarwal

OTHER

Sponsor Role: lead

Responsible Party

Dr. Vivek Aggarwal

Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Other Identifiers

SGTTHESIS

Identifier Type: -

Identifier Source: org_study_id