Effect of Lidocaine/Dexamethasone on the Success of IANB

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-08-01

Study Completion Date

2017-12-01

Brief Summary

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The purpose of this prospective, randomized, double-blind study was to compare the success rate of IAN block injection carried out with two cartridges of 2% lidocaine with 1:80000 epinephrine each combined with 0.2 ml dexamethasone versus two cartridges of 2% lidocaine with 1:80000 epinephrine each combined with 0.2 ml sterile distilled water for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.

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Detailed Description

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Several investigations have been carried out to demonstrate the effect of dexamethasone added to local anesthetics in regional block injections. These investigations shown that the addition of dexamethasone to local anaesthetics may prolong the duration of anesthesia and also results in a faster onset. It is hypothesized that dexamethasone added to lidocaine may affect the success rate of inferior alveolar nerve block

Conditions

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Local Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Dexamethasone

lidocaine \& Dexamethasone

Group Type EXPERIMENTAL

2% lidocaine with 1:80,000 epinephrine

Intervention Type DRUG

Anesthetic solution

Dexamethasone

Intervention Type DRUG

Corticostroide

Non-dexamethasone

lidocaine \& Placebo

Group Type PLACEBO_COMPARATOR

2% lidocaine with 1:80,000 epinephrine

Intervention Type DRUG

Anesthetic solution

Placebo

Intervention Type DRUG

Placebo

Interventions

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2% lidocaine with 1:80,000 epinephrine

Anesthetic solution

Intervention Type DRUG

Dexamethasone

Corticostroide

Intervention Type DRUG

Placebo

Intervention Type DRUG

Other Intervention Names

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lidocaine (2% Persocaine-E; Daroupakhsh, Tehran, Iran) Dexamethasone (Caspian Tamin Pharmaceutical Co, Rasht, Iran) sterile distilled water (Samen Pharmaceutical Co, Iran)

Eligibility Criteria

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Inclusion Criteria

* vital mandibular molar tooth
* diagnosis of symptomatic irreversible pulpitis

Exclusion Criteria

* younger than 18 years old
* history of significant medical conditions
* allergies to local anesthetics or sulfites
* pregnancy
* taking any medications that might influence anesthetic assessment
* active sites of pathosis in area of injection
* inability to give informed consent

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes