AI ECHO INSIGHT RCT for Automated Echo Reporting

NCT ID: NCT07229300

Last Updated: 2025-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-01

Study Completion Date

2026-06-01

Brief Summary

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The goal of this blinded randomized controlled trial is to assess whether AI-assisted TTE interpretation can improve cardiologist efficiency and reduce interpretation variability while preserving accuracy compared to current methods in adult patients whose historical echocardiogram images were performed.

The main questions it aims to answer is to:

1. Assess overall transthoracic echocardiogram (TTE) interpretation accuracy of an AI-assisted workflow compared to standard cardiologist-only and sonographer-assisted workflows to hypothesize if AI-assisted workflow for echocardiography interpretation is non-inferior in accuracy compared to standard workflows.
2. Evaluate cardiologist interpretation time using an AI-assisted workflow compared to standard cardiologist-only and sonographer-assisted workflows to determine if an AI-assisted workflow will result in a decrease in interpretation time compared to the cardiologist-only workflow.
3. To compare interpretation consistency and reliability compared to historical reports as well as consensus reports of all finalized cardiologist reports.

Detailed Description

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Conditions

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Echocardiography, Transthoracic Echocardiographic Software

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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AI-Assisted Interpretation

In AI-prelim arm, AI provides the preliminary interpretation which is finalized by a blinded cardiologist.

Group Type ACTIVE_COMPARATOR

AI-Assisted Echocardiogram Interpretation

Intervention Type OTHER

Echocardiogram studies are pre-interpreted by the AI software and finalized by a blinded cardiologist.

Sonographer-Assisted Interpretation

In Sonographer-prelim arm, sonographer provides the preliminary interpretation which is finalized by a blinded cardiologist.

Group Type ACTIVE_COMPARATOR

Sonographer-Assisted Echocardiogram Interpretation

Intervention Type OTHER

(Standard of Care 1): Echocardiogram studies are pre-interpreted by a sonographer and finalized by a blinded cardiologist.

Cardiologist-Only Interpretation

In cardiologist-prelim arm, cardiology provides the preliminary interpretation which is finalized by a blinded separate cardiologist.

Group Type ACTIVE_COMPARATOR

Cardiologist-Only Echocardiogram Interpretation

Intervention Type OTHER

(Standard of Care 2): Echocardiogram studies are interpreted solely by two cardiologists (one provides a preliminary interpretation another provides a blinded final interpretation).

Interventions

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AI-Assisted Echocardiogram Interpretation

Echocardiogram studies are pre-interpreted by the AI software and finalized by a blinded cardiologist.

Intervention Type OTHER

Sonographer-Assisted Echocardiogram Interpretation

(Standard of Care 1): Echocardiogram studies are pre-interpreted by a sonographer and finalized by a blinded cardiologist.

Intervention Type OTHER

Cardiologist-Only Echocardiogram Interpretation

(Standard of Care 2): Echocardiogram studies are interpreted solely by two cardiologists (one provides a preliminary interpretation another provides a blinded final interpretation).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* ≥ 18 years of age
* Comprehensive transthoracic echocardiogram study performed a KPNC Medical Center.

Exclusion Criteria

* Known Congenital heart disease study
* Known Ventricular assist device
* Limited transthoracic echocardiogram study
* Transesophageal echocardiogram study
* Stress echocardiogram study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kaiser Permanente

OTHER

Sponsor Role lead

Responsible Party

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David Ouyang

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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David Ouyang

Role: PRINCIPAL_INVESTIGATOR

Kaiser Permanente

Keane K Lee

Role: PRINCIPAL_INVESTIGATOR

Kaiser Permanente

Locations

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Kaiser Permanente Northern California Division of Research

Pleasanton, California, United States

Site Status

Countries

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United States

Other Identifiers

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2302504

Identifier Type: -

Identifier Source: org_study_id

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