Point-of-Care Echocardiography in Patients with Known or Suspected Aortic Stenosis

NCT ID: NCT06717373

Last Updated: 2025-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-02-07

Study Completion Date

2025-04-01

Brief Summary

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This is a prospective clinical trial intended to capture echocardiographic images in patients clinically indicated for an echocardiographic examination using an additional Point of Care Ultrasound device . The images collected will be used to test and possibly validation an AI base Aortic Valve Stenosis algorithm

Detailed Description

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This is a non-randomized, un-blinded single-arm study in patients scheduled for a standard echocardiographic examination. Participants will be scanned by a sonographer (Study Exam) and 6 standard views will be obtained using both the ultrasound systems: PLAX, PSAX-AV, AP4, AP2, AP3 and AP5 .

The patient will undergo their scheduled echocardiographic examination either before or after the study examinations.

The findings from the clinically indicated echocardiographic examination will be used as a gold standard for the presence/absence and severity of aortic stenosis.

The first 45 patients, 15 with mild, 15 with moderate and 15 with severe AS, will be used for testing and possible fine-tuning the AutoAS algorithm for each Study Device, and the remaining up to 155 patients for each Study Device will be used for clinical validation of the algorithm. Because these first 45 patients will only be used for possible fine-tuning the AutoAS algorithm, they will be excluded from endpoint analysis.

Conditions

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Patients with an Indication for an Echocardiographic Examination with Suspicion of Valcular Heart Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

This is a prospective, non-randomized, un-blinded study in patients scheduled for a standard echocardiographic examination.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Single Arm

There is no investigational device being used. Devices to be used are Vscan Air and Venue Ultrasound systems

Group Type OTHER

AutoAS

Intervention Type DEVICE

AutoAS is an artificial intelligence algorithm that will be tested retrospectively on the images acquired as part of the study

Interventions

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AutoAS

AutoAS is an artificial intelligence algorithm that will be tested retrospectively on the images acquired as part of the study

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for an echocardiographic examination
* Patients ≥18 years old
* Patient with known or suspected valve disease based on medical history

Exclusion Criteria

* Patients with artificial aortic valves
* Unable to lie flat for study
* Patients experiencing a known or suspected acute cardiac event
* Patients unwilling or unable to give written informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Caption Health, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Akhil Narang, MD

Role: PRINCIPAL_INVESTIGATOR

Northwestern University

Locations

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Northwestern University

Chicago, Illinois, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Yngvil K Thomas, MSc

Role: CONTACT

+1 312-316-5632

Angeline Trinidad, BA

Role: CONTACT

+1 310-940-9162

Other Identifiers

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CH_AutoAS_2024

Identifier Type: -

Identifier Source: org_study_id

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