Echocardiography in Cardiac Resynchronization Therapy (Echo-CRT)
NCT ID: NCT02986633
Last Updated: 2018-07-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1000 participants
OBSERVATIONAL
2014-12-31
2025-12-31
Brief Summary
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Detailed Description
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Classical parameters of dyssynchrony obtained by conventional methods of echocardiography (including doppler tissue imaging) have a limited value in predicting CRT response. Meanwhile, patients with a Left Bundle Branch Block (LBBB) on the electrocardiogram experience more frequently LV reverse remodelling than those without a LBBB.
LBBB is responsible for specific LV contractile abnormalities that can be identified by speckle tracking strain echocardiography (early septal contraction, stretching of late contraction of the postero-lateral wall). The predictive value of these abnormalities remains to be studied.
Thus, it has been hypothesised that these LBBB-related contractile abnormalities may be independent predictors of LV reverse remodelling and outcome following CRT.
The present observational prospective study aims at identifying echocardiographic parameters (based on the LBBB-like contraction of the LV ascertained using new methods of echocardiography including speckle tracking strain) that are linked to CRT response and a better outcome following CRT.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with heart failure and CRT
Heart failure with left ventricular ejection fraction less than 35 % treated with CRT
Echocardiography
Interventions
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Echocardiography
Eligibility Criteria
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Inclusion Criteria
* QRS duration over than 120 ms
* Clinical indication for CRT
Exclusion Criteria
* Rythmologic indication of CRT for left ventricular ejection fraction between 35% and 45%
18 Years
ALL
No
Sponsors
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Lille Catholic University
OTHER
Responsible Party
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Principal Investigators
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Sylvestre Maréchaux, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Hospital of Lille Catholic University (GHICL)
Locations
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Hospitals of Lille Catholic University (GHICL)
Lomme, , France
Countries
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Central Contacts
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Facility Contacts
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References
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Layec J, Decroocq M, Delelis F, Appert L, Guyomar Y, Riolet C, Dumortier H, Mailliet A, Tribouilloy C, Marechaux S, Menet A. Dyssynchrony and Response to Cardiac Resynchronization Therapy in Heart Failure Patients With Unfavorable Electrical Characteristics. JACC Cardiovasc Imaging. 2023 Jul;16(7):873-884. doi: 10.1016/j.jcmg.2022.12.023. Epub 2023 Mar 8.
Appert L, Menet A, Altes A, Ennezat PV, Bardet-Bouchery H, Binda C, Guyomar Y, Delelis F, Castel AL, Le Goffic C, Guerbaai RA, Graux P, Tribouilloy C, Marechaux S. Clinical Significance of Electromechanical Dyssynchrony and QRS Narrowing in Patients With Heart Failure Receiving Cardiac Resynchronization Therapy. Can J Cardiol. 2019 Jan;35(1):27-34. doi: 10.1016/j.cjca.2018.10.019. Epub 2018 Nov 14.
Other Identifiers
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OBS-009
Identifier Type: -
Identifier Source: org_study_id
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