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Left Ventricular Dysfunction in Critically Ill Patients

NCT ID: NCT03787810

Last Updated: 2020-04-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

428 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-28

Study Completion Date

2020-02-20

Brief Summary

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Left ventricular dysfunction is common in the critically ill. The aim of this study is to assess the incidence and prognosis of left ventricular dysfunction in critically ill patients.

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Detailed Description

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Left ventricular dysfunction is common in the critically ill. A number of conditions can cause left ventricular dysfunction including myocardial infarction, septic cardiomyopathy, post resuscitation syndrome, takotsubo syndrome etc. A number of studies have assessed cardiac dysfunction in specific conditions (e.g. sepsis, cardiac arrest) but only a few studies have assessed cardiac dysfunction in a general ICU-population. The study will focus on diagnostics of the different types of cardiomyopathy and differentiating between ischemic and non-ischemic left ventricular dysfunction in a general ICU population. The aim of this study is to assess the incidence and prognosis of the different types of left ventricular dysfunction in critically ill patients. Our hypothesis is that left ventricular dysfunction is common in the critically ill and is associated with an increased risk of short-term death.

Conditions

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Left Ventricular Dysfunction Critically Ill Acute Coronary Syndrome Cardiomyopathies Takotsubo Cardiomyopathy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Echocardiography

Echocardiography for assessment of left ventricular dysfunction

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Admitted within 24 hours to the ICU
* Dysfunction of at least one organ system, defined as at least +1 point in SOFA-score.

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sahlgrenska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jonatan Oras

Consultant, adjunct senior lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jonatan Oras, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Sahlgrenska Academy, University of Gothenburg

Locations

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Sahlgrenska University Hospital

Gothenburg, Västra Götalandsregionen, Sweden

Site Status

Countries

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Sweden

References

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Cavefors O, Ljung Faxen U, Bech-Hanssen O, Lundin S, Ricksten SE, Redfors B, Oras J. Isolated diastolic dysfunction is associated with increased mortality in critically ill patients. J Crit Care. 2023 Aug;76:154290. doi: 10.1016/j.jcrc.2023.154290. Epub 2023 Mar 20.

Reference Type DERIVED
PMID: 36947970 (View on PubMed)

Other Identifiers

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LEVEDYCIP

Identifier Type: -

Identifier Source: org_study_id

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