Left Ventricular Myocardial Work for Predicting Response to CRT
NCT ID: NCT07319065
Last Updated: 2026-01-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
3240 participants
OBSERVATIONAL
2026-01-01
2027-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Healthy Adults Group
Healthy adults aged 18 to 79 years are planned to be stratified into 6 age groups: 18-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, and ≥70 years. Each age group will include 120 participants of each sex.
No interventions assigned to this group
Patients with heart failure and left bundle branch block who are scheduled to undergo CRT treatment
Ultrasound machine LVEF ≤ 35%; QRS ≥ 150ms; LBBB; Optimal drug therapy for at least 3 months before implantation 600 participants
Ultrasound machine
Myocardial work is a recently developed non-invasive method that incorporates the LV afterload into the overall longitudinal strain (GLS) analysis of echocardiography. Myocardial work reflects the contractile ability of the heart, stroke work per beat, residual myocardial contractile ability, myocardial oxygen consumption, useless work, and useful work, which is represented by the pressure-volume loop analysis and thus has the potential to predict the efficacy of CRT.
Patients with LBBB who have preserved LVEF
LVEF≥53%； LBBB 600 participants
Ultrasound machine
Myocardial work is a recently developed non-invasive method that incorporates the LV afterload into the overall longitudinal strain (GLS) analysis of echocardiography. Myocardial work reflects the contractile ability of the heart, stroke work per beat, residual myocardial contractile ability, myocardial oxygen consumption, useless work, and useful work, which is represented by the pressure-volume loop analysis and thus has the potential to predict the efficacy of CRT.
Patients with reduced LVEF but without LBBB
LVEF ≤ 35%, non-LBBB 600 participants
Ultrasound machine
Myocardial work is a recently developed non-invasive method that incorporates the LV afterload into the overall longitudinal strain (GLS) analysis of echocardiography. Myocardial work reflects the contractile ability of the heart, stroke work per beat, residual myocardial contractile ability, myocardial oxygen consumption, useless work, and useful work, which is represented by the pressure-volume loop analysis and thus has the potential to predict the efficacy of CRT.
Interventions
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Ultrasound machine
Myocardial work is a recently developed non-invasive method that incorporates the LV afterload into the overall longitudinal strain (GLS) analysis of echocardiography. Myocardial work reflects the contractile ability of the heart, stroke work per beat, residual myocardial contractile ability, myocardial oxygen consumption, useless work, and useful work, which is represented by the pressure-volume loop analysis and thus has the potential to predict the efficacy of CRT.
Eligibility Criteria
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Inclusion Criteria
1. Of Han Chinese ethnicity
2. Aged 18-79 years
3. Normal blood pressure (\< 140/90 mmHg)
4. Normal fasting blood glucose
5. Normal blood lipid levels (triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein)
6. Normal complete blood count results (hemoglobin concentration, white blood cell count, red blood cell count, platelet count)
7. Normal liver and renal function (alanine transaminase \< 2× upper limit of normal; normal creatinine and blood urea nitrogen)
8. Normal electrocardiogram results (occasional atrial premature beats may be enrolled at the investigator's discretion)
9. No structural heart disease and normal cardiac function confirmed by echocardiography
1. LVEF ≤ 35%
2. QRS ≥ 150ms; LBBB
3. At least 3 months of optimal drug therapy before implantation
1. LVEF≥53%
2. LBBB
1. LVEF ≤ 35%
2. non-LBBB
Exclusion Criteria
1. Clinically significant cardiac valve regurgitation (≥ mild severity)
2. Respiratory diseases: acute or chronic respiratory disorders
3. Endocrine diseases: thyroid disease, diabetes mellitus, hyperaldosteronism, pheochromocytoma, etc.
4. Abnormal liver function (alanine transaminase \> 2× upper limit of normal), abnormal renal function (elevated creatinine beyond normal range), or dyslipidemia (elevated triglycerides, total cholesterol, low-density lipoprotein, or high-density lipoprotein)
5. Other systemic diseases: anemia, malignancy, connective tissue disease, large artery/peripheral vascular diseases (aortic dilation, aortic dissection, coarctation of the aorta, Takayasu arteritis, atherosclerosis), etc.
6. Pregnant or lactating women
7. Professional athletes
8. Poor-quality ultrasound images that cannot support parameter measurement and analysis
Heart failure patients with LBBB who are scheduled for CRT treatment Group
1. Suffering from connective tissue diseases such as systemic lupus erythematosus, polymyositis, and rheumatoid arthritis;
2. Having a history of blood diseases and severe systemic diseases such as infections;
3. Those who cannot cooperate with the examinations.
Patients with LBBB who have preserved LVEF Group
1. Suffering from connective tissue diseases such as systemic lupus erythematosus, polymyositis, and rheumatoid arthritis;
2. Having a history of blood diseases and severe systemic diseases such as infections;
3. Those who cannot cooperate with the examinations.
Patients with reduced LVEF but without LBBB Group
1. Suffering from connective tissue diseases such as systemic lupus erythematosus, polymyositis, and rheumatoid arthritis;
2. Having a history of blood diseases and severe systemic diseases such as infections;
3. Those who cannot cooperate with the examinations.
18 Years
79 Years
ALL
Yes
Sponsors
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First Hospital of China Medical University
OTHER
Responsible Party
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Chunyan Ma
Chief of Cardiovascular Ultrasound
Principal Investigators
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Chunyan Ma, MD
Role: PRINCIPAL_INVESTIGATOR
First Hospital of China Medical University
Locations
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Anhui University of Chinese Medicine First Affiliated Hospital
Hefei, Anhui, China
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
The First Affiliated Hospital of Wannan Medical College
Wannan, Anhui, China
The Provincial Hospital Affiliated to Fuzhou University
Fuzhou, Fujian, China
Fujian Provincial Geriatric Hospital
Guizhou, Fujian, China
Guizhou Provincial People's Hospital
Guizhou, Fujian, China
Union Hospital Affiliated to Fujian Medical University
Guizhou, Fujian, China
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China
Zhongshan Hospital Affiliated to Xiamen University
Xiamen, Fujian, China
Gansu Provincial People's Hospital
Lanzhou, Gansu, China
Jiangmen Central Hospital
Jiangmen, Guangdong, China
The First Hospital of Qinhuangdao City
Qinhuangdao, Hebei, China
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The Third Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Longnan Hospital of Daqing Oilfield General Hospital
Daqing, Heilongjiang, China
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Heinan, China
FuWai Central China Cardiovascular Hospital
Zhengzhou, Henan, China
The First Affiliated Hospital of Henan Medical University (Xinxiang Medical University)
Zhengzhou, Henan, China
The First Affiliated Hospital of Henan University of Chinese Medicine
Zhengzhou, Henan, China
Enshi Central Hospital
Enshi, Hubei, China
Puai Hospital of Wuhan City / The Fourth Hospital of Wuhan City
Wuhan, Hubei, China
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Xiangyang Hospital of Traditional Chinese Medicine, Hubei Province
Xiangyang, Hubei, China
Changzhou Second People's Hospital
Changzhou, Jiangsu, China
The First People's Hospital of Lianyungang City
Lianyungang, Jiangsu, China
Jiangsu Provincial People's Hospital
Nanjing, Jiangsu, China
The First People's Hospital of Nantong City
Nantong, Jiangsu, China
The Third People's Hospital of Nantong City
Nantong, Jiangsu, China
Suqian Hospital of Jiangsu Provincial People's Hospital
Suqian, Jiangsu, China
The Hospital of Traditional Chinese Medicine of Suzhou City
Suzhou, Jiangsu, China
The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
The Affiliated Hospital of Jiangnan University
Wuxi, Jiangsu, China
The People's Hospital of Wuxi City
Wuxi, Jiangsu, China
Su Bei People's Hospital
Yangzhou, Jiangsu, China
The First Affiliated Hospital of Guizhou Medical University
Guizhoucun, Jiangxi, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
The First Hospital of Jilin University
Jilin, Jilin, China
The Second Hospital of Jilin University
Jilin, Jilin, China
Central Hospital of Anshan City
Anshan, Liaoning, China
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China
The First Hospital of China Medical University
Shenyang, Liaoning, China
Liaoning Golden Autumn Hospital
Shenyang, Liaoning, China
Shengjing Hospital, China Medical University
Shenyang, Liaoning, China
Chifeng Hospital
Chifeng, Neimenggu, China
The People's Hospital of Ningxia Hui Autonomous Region
Yinchuan, Ningxia, China
Jinan Central Hospital
Jinan, Shandong, China
The First Affiliated Hospital of Shandong First Medical University
Jinan, Shandong, China
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
Bethea Hospital of Shanxi Province
Taiyuan, Shanxi, China
Shanxi Cardiovascular Hospital (Shanxi Cardiovascular Hospital Research Institute)
Taiyuan, Shanxi, China
The Cancer Hospital of Shanxi Province
Taiyuan, Shanxi, China
The People's Hospital of Shanxi Province
Taiyuan, Shanxi, China
Tangdu Hospital, Air Force Medical University
Xi’an, Shanxi, China
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
The People's Hospital of Sichuan Province
Chengdu, Sichuan, China
Xindu District People's Hospital of Chengdu City
Chengdu, Sichuan, China
Affiliated Hospital of North Sichuan Medical College
Nanchong, Sichuan, China
The People's Hospital of Ya'an City
Ya'an, Sichuan, China
Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine / The Fourth Affiliated Hospital of Xinjiang Medical University
Xinjiang, Xinjiang, China
Dianxi Central Hospital of Yunnan Province
Dingxi, Yunnan, China
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
Yan'an Hospital of Kunming City
Kunming, Yunnan, China
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
The Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Lihuili Hospital of Ningbo Medical Center
Ningbo, Zhejiang, China
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, China
The Second Hospital of Ningbo City
Ningbo, Zhejiang, China
The Second Hospital of Shaoxing City
Shaoxing, Zhejiang, China
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
The People's Hospital of Zhuji City
Zhuji, Zhejiang, China
The First Hospital of Peking University
Beijing, , China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, , China
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, , China
Shanghai Chest Hospital
Shanghai, , China
The First Affiliated Hospital of Xinjiang Medical University
Xinjiang, , China
Countries
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Central Contacts
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Facility Contacts
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Jie Zhang
Role: primary
Xuegong Shi
Role: primary
Yuanyuan Ji
Role: primary
Yan Zhang
Role: primary
Ming Li
Role: primary
Ying Li
Role: primary
Jinguo Li
Role: primary
Yan Ge
Role: primary
Guohui Yan
Role: primary
Yuanyuan Chu
Role: primary
Zhongzhou Su
Role: primary
Chong Zhao
Role: primary
Chang Lv
Role: primary
Ming Liu
Role: primary
Ling Zhang
Role: primary
Ning Yang
Role: primary
Xin Zhang
Role: primary
Lin Liu
Role: primary
Juan Cong
Role: primary
Ran Li
Role: primary
Fei Wang
Role: primary
Kaiquan Wang
Role: primary
Bingyi Zhang
Role: primary
Yani Liu
Role: primary
Yuman Li
Role: primary
Wei Shi
Role: primary
Chang Liu
Role: primary
Yan Wang
Role: primary
Yonghong Yong
Role: primary
Li Ma
Role: primary
Hui Liu
Role: primary
Huijun Lai
Role: primary
Changsheng Ma
Role: primary
Qi Sun
Role: primary
Dajun Qian
Role: primary
Yong Chen
Role: primary
Sha Li
Role: primary
Xinchun Yuan
Role: primary
Yong Qian
Role: primary
Dongmei Lv
Role: primary
Yao Wang
Role: primary
Tao Cong
Role: primary
Chunyan Ma, MD
Role: backup
Jianfeng Cao
Role: primary
Lin Gao
Role: primary
Zhiying Cheng
Role: primary
Lihua Jin
Role: primary
Haiyan Wang
Role: primary
Yan Wen
Role: primary
Tianliang Li
Role: primary
Tianliang Li
Role: primary
Runqin Miao
Role: primary
Weiqin Li
Role: primary
Lianbi Zhao
Role: primary
Huanhuan Huo
Role: primary
Li Li
Role: primary
Yi Zhang
Role: primary
Jie Fang
Role: primary
Sha Tang
Role: primary
Yong Zhou
Role: primary
Yu Wang
Role: primary
Zhe Meng
Role: primary
Pei Wang
Role: primary
Yan Cheng
Role: primary
Wei Wu
Role: primary
Shengmin Zhang
Role: primary
Kai Zheng
Role: primary
Gang Wang
Role: primary
Shusheng Liao
Role: primary
Yu Yang
Role: primary
Ying Yang
Role: primary
Qian Dong
Role: primary
Yang Sun
Role: primary
Fan Li
Role: primary
Lina Guan
Role: primary
Other Identifiers
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General Electric Healthcare
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
CARE-MW Study
Identifier Type: -
Identifier Source: org_study_id
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