Blinded Randomized Controlled Trial of Artificial Intelligence Guided Detection of Intracardiac Thrombus

NCT ID: NCT06206187

Last Updated: 2024-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

1500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-05

Study Completion Date

2025-12-31

Brief Summary

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To determine whether an integrated AI decision support can save time and improve the accuracy of detection of intracardiac thrombus, the investigators are conducting a blinded, randomized controlled study of AI-guided detection of intracardiac thrombus to electrophysiologist judgment in preliminary readings of echocardiograms.

Detailed Description

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Conditions

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Atrial Fibrillation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Electrophysiologist judgment

Group Type ACTIVE_COMPARATOR

Electrophysiologist judgment of the intracardiac thrombus

Intervention Type OTHER

Cardiac electrophysiologists use their own experience to determine whether there is intracardiac thrombus

Artificial Intelligence Detection

Group Type EXPERIMENTAL

Automated detection of the intracardiac thrombus through deep learning

Intervention Type OTHER

A deep learning model will identify the intracardiac thrombus. The AI model will produce an assessment of intracardiac thrombus using video based features.

Interventions

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Automated detection of the intracardiac thrombus through deep learning

A deep learning model will identify the intracardiac thrombus. The AI model will produce an assessment of intracardiac thrombus using video based features.

Intervention Type OTHER

Electrophysiologist judgment of the intracardiac thrombus

Cardiac electrophysiologists use their own experience to determine whether there is intracardiac thrombus

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Aged 18-80 years.
2. Willing to sign informed consent.
3. Patients diagnosed with atrial fibrillation Paroxysmal AF and Persistent AF according to the latest clinical guidelines

Exclusion Criteria

1. End-stage disease with a mean life expectancy less than 1 year
2. New York Heart Association (NYHA) class III or IV, or last known left ventricular ejection fraction less than 30%
3. Previous surgical or catheter ablation for AF
4. Bradycardia and presence of implanted ICD
5. Uncontrolled hypertension: Systolic blood pressure (SBP) \>180 mmHg or diastolic blood pressure (DBP) \> 110 mmHg
6. Patients with Cardiovascular events including acute myocardial infarction, any PCI, valvular cardiac surgical, or percutaneous procedure within the past 3 months
7. Women of childbearing potential who are, or plan to become, pregnant during the time of the study
8. Have been enrolled in an investigational study evaluating devices or drugs.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Johnson & Johnson

INDUSTRY

Sponsor Role collaborator

Shanghai Chest Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xu Liu

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Shanghai Chest Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Central Contacts

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Shaohui Wu, PHD

Role: CONTACT

15821960839

Facility Contacts

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绍辉 吴

Role: primary

15821960839

Other Identifiers

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ICE Detector-RCT

Identifier Type: -

Identifier Source: org_study_id

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