Intervention for Communication Quality of Life in Primary Progressive Aphasia
NCT ID: NCT07219680
Last Updated: 2025-11-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
25 participants
INTERVENTIONAL
2026-01-03
2027-08-31
Brief Summary
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The main questions the study aims to answer are:
1. Is the telerehabilitation program feasible and acceptable for people with PPA and their care partners?
2. Do participants with PPA and care partners find treatment beneficial?
3. Which outcome measures are most useful for evaluating changes in communication and quality of life?
4. What patterns of treatment response are seen in participants after completing the program?
The program includes both speech-language therapy and training for care partners.
Participants with PPA will:
1. Complete virtual communication tasks and questionnaires before and after the program
2. Take part in online speech-language therapy sessions
3. Include their care partners in some parts of the program for training and support
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
Participants in Arm 2, the waitlist control group, will undergo initial assessment followed by a waiting interval of 10 (Multi-VISTA) or 12 (Multi-LRT) weeks. Following the waiting period, they will be reassessed for cognitive-linguistic and participant-reported outcome measures prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRT treatment).
TREATMENT
NONE
Study Groups
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Waitlist Control
Individuals in the waitlist-control group will undergo initial assessment followed by a waiting interval of 10 (Multi-VISTA) or 12 (Multi-LRT) weeks. Following the waiting period, they will again complete baseline assessments prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRT treatment).
Multicomponent Lexical Retrieval Training
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Biweekly (approximately one hour each) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets four times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Multicomponent Video Implemented Script Training in Aphasia
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (approximately one hour each) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Immediate Treatment
Individuals in the immediate treatment group will undergo initial assessment followed immediately by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRT treatment).
Multicomponent Lexical Retrieval Training
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Biweekly (approximately one hour each) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets four times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Multicomponent Video Implemented Script Training in Aphasia
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (approximately one hour each) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Interventions
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Multicomponent Lexical Retrieval Training
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Biweekly (approximately one hour each) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets four times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Multicomponent Video Implemented Script Training in Aphasia
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (approximately one hour each) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* MMSE score of \> 15 and must be able to produce single monosyllabic words intelligibly.
* Must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
* Hearing and vision adequate for participation in teleconference meetings
* Must have a care partner available (someone who will commit to attending teleconference sessions weekly during treatment phases)
* Partners must express willingness to attend and participate in treatment sessions including those targeting dyadic communication goals
* Partners must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
* Partner's hearing and vision should be adequate for participation in teleconference meetings
Exclusion Criteria
* Psychiatric diagnosis that can account for symptoms
* The participant and/or study partner must have basic experience using a computer.
40 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
National Institute on Aging (NIA)
NIH
University of Texas at Austin
OTHER
Responsible Party
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Principal Investigators
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Maya L Henry, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Texas - Austin
Stephanie M Grasso, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Texas - Austin
Locations
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University of Texas
Austin, Texas, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Henry ML, Hubbard HI, Grasso SM, Mandelli ML, Wilson SM, Sathishkumar MT, Fridriksson J, Daigle W, Boxer AL, Miller BL, Gorno-Tempini ML. Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain. 2018 Jun 1;141(6):1799-1814. doi: 10.1093/brain/awy101.
Henry ML, Hubbard HI, Grasso SM, Dial HR, Beeson PM, Miller BL, Gorno-Tempini ML. Treatment for Word Retrieval in Semantic and Logopenic Variants of Primary Progressive Aphasia: Immediate and Long-Term Outcomes. J Speech Lang Hear Res. 2019 Aug 15;62(8):2723-2749. doi: 10.1044/2018_JSLHR-L-18-0144. Epub 2019 Aug 7.
Dial HR, Hinshelwood HA, Grasso SM, Hubbard HI, Gorno-Tempini ML, Henry ML. Investigating the utility of teletherapy in individuals with primary progressive aphasia. Clin Interv Aging. 2019 Feb 25;14:453-471. doi: 10.2147/CIA.S178878. eCollection 2019.
Related Links
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University of Texas Aphasia Research and Treatment Lab
University of Texas Aphasia Multilingual Aphasia and Dementia Research Lab
Other Identifiers
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