Primary Progressive Aphasia Multicomponent Language Treatment Study

NCT ID: NCT06649084

Last Updated: 2025-10-08

Basic Information

• Recruitment Status: ENROLLING_BY_INVITATION
• Clinical Phase: NA
• Total Enrollment: 21 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-05-02
• Study Completion Date: 2025-12-31

Brief Summary

The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will also document how acceptable and helpful the program is for both patients and their care partners.

The main questions the study aims to answer are:

1. Is the telerehabilitation program feasible and acceptable for people with PPA and their care partners?

2. Do participants with PPA and care partners report satisfaction with the program?

3. Which outcome measures are most useful for evaluating changes in communication and quality of life?

4. What patterns of treatment response are seen in participants after completing the program?

Researchers will test the program in a small group of participants to see how people respond. The program includes both speech-language therapy and training for care partners.

Participants will:

• Take part in online speech-language therapy sessions
• Complete communication tasks and questionnaires before and after the program
• Have regular virtual check-ins with the research team
• Include their care partners in some parts of the program for training and support

Conditions

Primary Progressive Aphasia; Semantic Dementia; Semantic Memory Disorder; Logopenic Progressive Aphasia; Nonfluent Aphasia, Progressive; Aphasia; Aphasia, Progressive

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Multicomponent Lexical Retrieval Training (Multi-LRT)

Group Type: EXPERIMENTAL

Multicomponent Lexical Retrieval Training (Multi-LRT)

Intervention Type: BEHAVIORAL

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Treatment focuses on the use of strategies which capitalize on residual linguistic ability and autobiographical memory to support word retrieval. The participant completes two one-hour-long sessions per week plus daily homework. The participant also meets 4 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)

Group Type: EXPERIMENTAL

Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)

Intervention Type: BEHAVIORAL

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing personally relevant scripts of 3-5 sentences in length. Length and complexity of scripts are individually tailored. The participant completes 30 minutes per day of home practice, during which they speak in unison with a video/audio model of a healthy speaker clearly articulating the scripts. Biweekly (one hour each) sessions with a clinician are held which target clear and accurate script production, script memorization, and conversational usage of the script and multimodal communication. The participant also meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Experimental: Multicomponent Communicaiton Partner Training (Multi-CPT)

Group Type: EXPERIMENTAL

Multicomponent Communication Partner Training (Multi-CPT)

Intervention Type: BEHAVIORAL

In person or via teletherapy: A multi-component treatment incorporating elements of compensatory and care-partner focused interventions. Biweekly (one hour each) sessions with a clinician are held which target use of communication strategies including multimodal communication for the participant and study partner (e.g., spouse). The participant also completes regular assignments meant to increase generalization of communication strategies and progress on personal goals.

Interventions

Multicomponent Lexical Retrieval Training (Multi-LRT)

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Treatment focuses on the use of strategies which capitalize on residual linguistic ability and autobiographical memory to support word retrieval. The participant completes two one-hour-long sessions per week plus daily homework. The participant also meets 4 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Intervention Type: BEHAVIORAL

Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing personally relevant scripts of 3-5 sentences in length. Length and complexity of scripts are individually tailored. The participant completes 30 minutes per day of home practice, during which they speak in unison with a video/audio model of a healthy speaker clearly articulating the scripts. Biweekly (one hour each) sessions with a clinician are held which target clear and accurate script production, script memorization, and conversational usage of the script and multimodal communication. The participant also meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Intervention Type: BEHAVIORAL

Multicomponent Communication Partner Training (Multi-CPT)

In person or via teletherapy: A multi-component treatment incorporating elements of compensatory and care-partner focused interventions. Biweekly (one hour each) sessions with a clinician are held which target use of communication strategies including multimodal communication for the participant and study partner (e.g., spouse). The participant also completes regular assignments meant to increase generalization of communication strategies and progress on personal goals.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
• Scores of 10 or higher on the Mini-Mental State Examination
• Has a study partner who can consistently attend sessions

Exclusion Criteria

• Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits
• Significant, uncorrected visual or hearing impairment that would interfere with participation
• Score of less than 10 on the Mini-Mental State Examination
• Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

Sponsor Role: collaborator

University of Texas at Austin

OTHER

Sponsor Role: lead

Responsible Party

Maya Henry

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Maya L Henry, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Texas - Austin

Locations

University of Texas

Austin, Texas, United States

Countries

United States

Other Identifiers

R56DC016291

Identifier Type: NIH

Identifier Source: secondary_id

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R56DC016291

Identifier Type: NIH

Identifier Source: org_study_id

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