Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma

NCT ID: NCT07195370

Last Updated: 2025-09-26

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-05-01
• Study Completion Date: 2026-01-01

Brief Summary

This study evaluates the effectiveness and safety of YAG laser peripheral iridotomy performed at two different locations (temporal and inferior) in patients with primary angle-closure glaucoma, a leading cause of blindness worldwide. Patients visiting the glaucoma clinic at Feiz Hospital who are candidates for peripheral iridotomy will participate. In each patient, one eye will receive a temporal iridotomy, and the other eye will receive an inferior iridotomy, with patients unaware of the location used in each eye. The study will measure outcomes such as laser power, intraocular pressure, visual symptoms, and complications over six months to determine which approach is more effective and safer.

Conditions

Glaucoma Eye; Angle Closure Glaucoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: NONE

Study Groups

Description: YAG laser peripheral iridotomy performed in the temporal region of one eye. Arm 2 Title

Group Type: OTHER

peripheral iridotomy

Intervention Type: OTHER

This procedure involves using a neodymium-doped yttrium aluminum garnet (YAG) laser to create a small hole in the temporal region of the iris in one eye. It aims to relieve intraocular pressure in patients with primary angle-closure glaucoma by improving the flow of aqueous humor. The procedure is performed under local anesthesia in a clinical setting, with patients unaware of which eye receives this treatment. Outcomes, including laser power, intraocular pressure, visual symptoms, and complications, are monitored over six months.

Interventions

peripheral iridotomy

This procedure involves using a neodymium-doped yttrium aluminum garnet (YAG) laser to create a small hole in the temporal region of the iris in one eye. It aims to relieve intraocular pressure in patients with primary angle-closure glaucoma by improving the flow of aqueous humor. The procedure is performed under local anesthesia in a clinical setting, with patients unaware of which eye receives this treatment. Outcomes, including laser power, intraocular pressure, visual symptoms, and complications, are monitored over six months.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

Adults (typically over 40 years old).

Ability to provide informed consent.

Narrow or closed anterior chamber angle (based on gonioscopy).

Intraocular pressure (IOP) controlled with medication but requiring surgery.

No previous iridotomy.

Exclusion Criteria

Active eye diseases (e.g., infection or inflammation).

Advanced cataracts or lens-related issues.

Severe visual impairment (e.g., less than 20/200 vision).

Uncontrolled systemic diseases (e.g., diabetes or cardiovascular disease).

Pregnancy or breastfeeding.

Previous eye surgery (except for minor procedures).

Inability to follow-up with scheduled visits.

-

• Minimum Eligible Age: 24 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Isfahan University of Medical Sciences

OTHER

Sponsor Role: lead

Responsible Party

Afsaneh Naderi Beni

IsfahanUMS

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Isfahan University of Medical Sciences

Isfahan, Isfahan, Iran

Countries

Iran

Other Identifiers

IR.MUI.MED.REC.1401.153

Identifier Type: OTHER

Identifier Source: secondary_id

feiz-123456

Identifier Type: -

Identifier Source: org_study_id