Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2020-07-01
2021-03-31
Brief Summary
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Detailed Description
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Laser peripheral iridectomy is recognized as the best surgical method to relieve pupil block. Previous studies have shown increased anterior chamber depth (ACD), area (ACA), and volume (ACV), and increased Angle open distance (AOD) after LPI surgery.
However, postoperative outcomes of LPI were not the same for patients with different angle closure mechanisms.
Postoperative outcomes for LPI were best for patients with pupillary block type, but were moderate for patients with plateau iris group and mixed group.
The purpose of this study, conducted in Chinese subjects, aims to use UBM to evaluate changes in the anterior segment parameters of LPI, and to propose methods to predict postoperative outcomes of LPI.
Conditions
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Keywords
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Pupillary block group
According to the configurations of angle closure, the pupillary block group is defined as the iris bombe.
pupillary block group
According to the configurations of angle closure, the pupillary block group is defined as the iris bombe.
plateau iris group
According to the configurations of angle closure, the plateau iris group is defined as the thickness of the peripheral iris.
plateau iris group
According to the configurations of angle closure, the plateau iris group is defined as the thickness of the peripheral iris.
mixed mechanism group
According to the configurations of angle closure, the mixing mechanism group is defined as the iris bombe plus thickening of the peripheral iris.
mixing mechanism group
According to the configurations of angle closure, the mixing mechanism group is defined as the iris bombe plus thickening of the peripheral iris.
Interventions
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pupillary block group
According to the configurations of angle closure, the pupillary block group is defined as the iris bombe.
plateau iris group
According to the configurations of angle closure, the plateau iris group is defined as the thickness of the peripheral iris.
mixing mechanism group
According to the configurations of angle closure, the mixing mechanism group is defined as the iris bombe plus thickening of the peripheral iris.
Eligibility Criteria
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Inclusion Criteria
2. received ultrasound Biomicroscopy before and after laser peripheral iridotomy;
3. Voluntary participation in this study;
4. Have enough language comprehension ability;
5. Patient or his legal representative has sign the informed consent.
Exclusion Criteria
2. previous intraocular surgery or penetrating eye injury;
3. media opacity preventing laser peripheral iridotomy;
4. Researchers think not suitable to participate in this clinical trial subjects;
5. Refused to sign the informed consent.;
6. There are important viscera function failure or other serious disease, including clinical related coronary artery disease, cardiovascular disease or myocardial infarction into the group of the first six months; serious neurological or psychiatric illness; serious infections; coagulant function abnormality; general active infectious diseases; malignant tumor; serious immune diseases.
20 Years
ALL
No
Sponsors
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Zhongshan Ophthalmic Center, Sun Yat-sen University
OTHER
Responsible Party
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Mingkai Lin
chief physician
Principal Investigators
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Mingkai Lin, MD
Role: STUDY_CHAIR
Zhongshan Ophthalmic Center, Sun Yat-San University
Locations
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Zhongshan Ophthalmic Center, Sun Yat-San Univerdity
Guangzhou, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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Yuying Zhou, Master
Role: primary
References
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He M, Jiang Y, Huang S, Chang DS, Munoz B, Aung T, Foster PJ, Friedman DS. Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial. Lancet. 2019 Apr 20;393(10181):1609-1618. doi: 10.1016/S0140-6736(18)32607-2. Epub 2019 Mar 14.
He M, Friedman DS, Ge J, Huang W, Jin C, Lee PS, Khaw PT, Foster PJ. Laser peripheral iridotomy in primary angle-closure suspects: biometric and gonioscopic outcomes: the Liwan Eye Study. Ophthalmology. 2007 Mar;114(3):494-500. doi: 10.1016/j.ophtha.2006.06.053. Epub 2006 Nov 21.
He M, Foster PJ, Ge J, Huang W, Zheng Y, Friedman DS, Lee PS, Khaw PT. Prevalence and clinical characteristics of glaucoma in adult Chinese: a population-based study in Liwan District, Guangzhou. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2782-8. doi: 10.1167/iovs.06-0051.
Other Identifiers
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2019KYPJ182
Identifier Type: -
Identifier Source: org_study_id