Effect of Yellow-Tinted Intraocular Lens on Standard Automated Perimetry (SAP) and Short-wavelength Automated Perimetry (SWAP) in Patients With and Without Glaucoma

NCT ID: NCT01305616

Last Updated: 2011-03-28

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-05-31
• Study Completion Date: 2010-01-31

Brief Summary

To investigate the effect of yellow-tinted IOLs on the Short Wave-length Automated Perimetry (SWAP) and Standard Automated Perimetry (SAP) in patients with and without glaucoma.

Detailed Description

Glaucoma is mostly a disease of old people and is highly accompanied with cataract.Some of these patients may need to perform cataract surgery during the course of glaucoma. But in glaucoma patients, the effect of cataract surgery and/or type of implanted intraocular lens (IOL) on the results of specific visual field tests, like SWAP, is still not well studied.From the past decade, various yellow-tinted IOLs with the speculation of protecting the retinal photoreceptors and decreasing the incidence of age-related macular degeneration have been introduced.These blue-light-filtering IOLs contain a yellow chromophore that filters ultra violet (UV) and a larger part of the high-energetic visible blue-light between 380 and 500 nm. Based on previous studies yellow-tinted IOLs decrease the amount of light transmission to the retina which may theoretically affect perimetry results. This might be even more important in patients with glaucoma where the sensitivity of test locations has decreased per se.

Since early diagnosis of glaucoma and its progression is highly dependent on visual field results, it is important to evaluate the effect of these IOLs on perimetry, particularly on SWAP, in which the blue-light-filtering IOLs might interfere with its findings.

Conditions

Cataract; Glaucoma

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Blinding Strategy: NONE

Study Groups

Group 1, glaucoma and cataract

Group1 were those patients with visually significant cataract (less than grade 2) and mild to moderate open angle glaucoma

Group Type: ACTIVE_COMPARATOR

Phacoemulsification with yellow-tinted intraocular lens

Intervention Type: PROCEDURE

Phacoemulsification is a kind of cataract surgery using ultrasound machine. Yellow-tinted intraocular lens are a sort of lens with the ability to filter blue and ultraviolet spectrum of light (380-500 nanometer)

Group2, cataract patients

This group included those patients with visually significant cataract and normal other eye examination.

Group Type: SHAM_COMPARATOR

Phacoemulsification with yellow-tinted intraocular lens

Intervention Type: PROCEDURE

Phacoemulsification is a kind of cataract surgery using ultrasound machine. Yellow-tinted intraocular lens are a sort of lens with the ability to filter blue and ultraviolet spectrum of light.

Interventions

Phacoemulsification with yellow-tinted intraocular lens

Phacoemulsification is a kind of cataract surgery using ultrasound machine. Yellow-tinted intraocular lens are a sort of lens with the ability to filter blue and ultraviolet spectrum of light (380-500 nanometer)

Intervention Type: PROCEDURE

Phacoemulsification with yellow-tinted intraocular lens

Phacoemulsification is a kind of cataract surgery using ultrasound machine. Yellow-tinted intraocular lens are a sort of lens with the ability to filter blue and ultraviolet spectrum of light.

Intervention Type: PROCEDURE

Other Intervention Names

bluelight filteing intraocular lens; bluelight filteing intraocular lens

Eligibility Criteria

Inclusion Criteria

• In group 1, visually significant cataract associated with well controlled mild to moderate open angle glaucoma (intraocular pressure < 18 with maximally-tolerated medical treatment)and no history of previous intraocular surgeries
• In group 2- Normal ophthalmic examination other than visually significant cataract

Exclusion Criteria

• Diabetes mellitus
• neurological disease which may affect the results of visual field
• known systemic medication with involvement on visual field
• spherical refractive error less than -5 and more than +5 diopter
• cylindrical correction more than 3 diopter

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Rassoul Akram Hospital

OTHER

Sponsor Role: lead

Responsible Party

Rassoul Akram Hospital,Ophthalmic Research Center,Department of Ophthalmology,Iran University of Medical Sciences

Principal Investigators

Naveed Nilforushan, M.D

Role: PRINCIPAL_INVESTIGATOR

Rassoul Akram hospital,Department of Ophthalmology,Iran University of Medical Sciences

Locations

Rassoul Akram Hospital

Tehran, Tehran Province, Iran

Countries

Iran

References

Jang SY, Ohn YH, Kim SW. Effect of yellow-tinted intraocular lenses on short-wavelength automated perimetry. Am J Ophthalmol. 2010 Aug;150(2):243-247.e1. doi: 10.1016/j.ajo.2010.02.023.

Reference Type: BACKGROUND

PMID: 20525530 (View on PubMed)

Kara-Junior N, Jardim JL, de Oliveira Leme E, Dall'Col M, Susanna R Jr. Effect of the AcrySof Natural intraocular lens on blue-yellow perimetry. J Cataract Refract Surg. 2006 Aug;32(8):1328-30. doi: 10.1016/j.jcrs.2006.03.033.

Reference Type: BACKGROUND

PMID: 16863969 (View on PubMed)

Other Identifiers

975

Identifier Type: -

Identifier Source: org_study_id