Ultrasound-Guided Subtransverse Interligamentary Block Versus Thoracic Paravertebral Block for Postoperative Analgesia in Patients Undergoing Open Nephrectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-23

Study Completion Date

2026-02-01

Brief Summary

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This study aims to compare ultrasound-guided subtransverse process interligamentary (STIL) block versus thoracic paravertebral block (TPVB) for postoperative analgesia in patients undergoing open nephrectomy.

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Detailed Description

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Acute pain physiopathology is explained as it is mediated by inflammatory cell infiltration, activation of spinal cord pain pathways, and also by reflexive muscle spasm. All of these three mechanisms of acute pain are typically ameliorated during the postoperative recovery.

A thoracic paravertebral block (TPVB) shows comparable analgesic efficacy with fewer side effects compared with thoracic epidural analgesia in patients undergoing thoracotomy.

The recently introduced subtransverse process interligamentary (STIL) block offers a safer alternative by targeting thoracic nerves without entering paravertebral space.

Conditions

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Subtransverse Interligamentary Block Thoracic Paravertebral Block Postoperative Analgesia Open Nephrectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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STIL group

Patients will receive subtransverse process interligamentary (STIL) block using 20ml of bupivacaine 0.25%.

Group Type EXPERIMENTAL

Subtransverse process interligamentary

Intervention Type OTHER

Patients will receive subtransverse process interligamentary (STIL) block using 20ml of bupivacaine 0.25%.

TPVB group

Patients will receive a thoracic paravertebral block (TPVB) using 20ml of bupivacaine 0.25%.

Group Type EXPERIMENTAL

Thoracic paravertebral block

Intervention Type OTHER

Patients will receive a thoracic paravertebral block (TPVB) using 20ml of bupivacaine 0.25%.

Interventions

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Subtransverse process interligamentary

Patients will receive subtransverse process interligamentary (STIL) block using 20ml of bupivacaine 0.25%.

Intervention Type OTHER

Thoracic paravertebral block

Patients will receive a thoracic paravertebral block (TPVB) using 20ml of bupivacaine 0.25%.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age from 18 to 65 years.
* Both sexes.
* American Society of Anesthesiology (ASA) physical status I-III.
* Undergoing open nephrectomy under general anesthesia.

Exclusion Criteria

* History of allergies to local anesthetics.
* Opioid dependency.
* Bleeding or coagulation disorders.
* Psychiatric and neurological disorder.
* Local infection at the site of injection.
* Body mass index (BMI) \> 35 kg/m2.
* Severe heart, lung, liver, and renal dysfunction.
* Pregnant or lactating women.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No