Periodontitis Severity in Patients With Diabetic Retinopathy
NCT ID: NCT07137013
Last Updated: 2025-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2025-02-24
2025-06-23
Brief Summary
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The main question this study seeks to answer is:
Do measurable changes in retinal layer thickness occur as periodontal disease severity increases in patients with diabetic retinopathy?
Participants will include adult individuals with a confirmed clinical diagnosis of DR. Periodontal status will be assessed through standard clinical parameters, including plaque index, probing pocket depth, clinical attachment loss, and bleeding on probing. Retinal layer thickness will be measured using high-resolution OCT and OCT angiography (OCTA) devices. The study aims to analyze potential associations between periodontal disease severity and morphological as well as vascular changes in the retina.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Study Groups
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Control
without systemic disease
No interventions assigned to this group
DM+ DR-
Diagnosed with Diabetes Mellitus and not diagnosed with Diabetic Retinopathy
No interventions assigned to this group
NPDR+ DMÖ-
Diagnosed with non-proliferative Diabetic Retinopathy without diabetic macular edema
No interventions assigned to this group
NPDR+ DMÖ+
Diagnosed with non-proliferative DR with diabetic macular edema
No interventions assigned to this group
PDR
Diagnosed with proliferative Diabetic Retinopathy
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Those without systemic disease (control group)
* Patients diagnosed with diabetic retinopathy
* Patients diagnosed with diabetes mellitus (HbA1c\>6)
Exclusion Criteria
* Patients taking immunosuppressive medications, oral contraceptives, or bisphosphonates
* Pregnancy
* Patients with acute or chronic eye diseases such as vitreoretinal, optic nerve, or choroidal vascular diseases, cataracts, glaucoma, retinal degeneration, uveitis, Behçet's disease, or scleritis
* Patients undergoing refractive or intraocular surgery
* Presence of active infectious disease (acute hepatitis, tuberculosis, AIDS)
* Chronic use of medications affecting periodontal tissues (cyclosporine A, phenytoin)
* Patients taking antioxidant supplements
60 Years
85 Years
ALL
Yes
Sponsors
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Recep Tayyip Erdogan University Training and Research Hospital
OTHER
Responsible Party
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Dilek KARADOĞAN
Assoc. Prof. Dr.
Locations
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Department of Ophthalmology of the Faculty of Medicine of Recep Tayyip Erdogan University
Rize, Rize Province, Turkey (Türkiye)
Countries
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Other Identifiers
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DR2025/59
Identifier Type: -
Identifier Source: org_study_id
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