Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

NCT ID: NCT07065747

Last Updated: 2025-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

125 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-01

Study Completion Date

2026-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Anterior Uveitis (AU) Birdshot Chorioretinitis Behcet Disease Herpes Simplex Virus Juvenile Idiopathic Arthritis (JIA) Spondyloarthritis (SA) Sarcoidosis Posterior Vitreous Detachment

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Uveitis Group

Eyes with active inflammation due to various systemic diseases

No interventions assigned to this group

Posterior Vitreous Detachment Group

Eyes with vitreous floaters and posterior vitreous detachment

No interventions assigned to this group

Healthy/Control Group

Healthy eyes with no history of uveitis, posterior vitreous detachment, or previous eye surgery

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
2. Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
3. Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.

Exclusion Criteria

1. Inability to give informed consent.
2. Inability to maintain stable fixation for OCT imaging.
3. Inability to commit to required visits to complete the study.
4. Pregnancy and breastfeeding.
Minimum Eligible Age

5 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

National Eye Institute (NEI)

NIH

Sponsor Role collaborator

Oregon Health and Science University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

David Huang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Yan Li, PhD

Role: PRINCIPAL_INVESTIGATOR

Oregon Health and Science University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Casey Eye Institute - Oregon Health & Science University

Portland, Oregon, United States

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Humberto Martinez, COT, MBA

Role: CONTACT

503-494-7712

Denzil Romfh, OD

Role: CONTACT

503-494-4351

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

R21EY036563

Identifier Type: NIH

Identifier Source: secondary_id

View Link

OHSU IRB0008052

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Imaging Quantification of Inflammation (IQI)
NCT04704609 ACTIVE_NOT_RECRUITING
Peripheral Retina Robotically Aligned OCT Study
NCT06451068 NOT_YET_RECRUITING NA
OCT Angiography in Wet AMD
NCT02253030 RECRUITING
Infectious Causes of Uveitis
NCT00676624 COMPLETED
Dual Wavelength OCT
NCT03843840 COMPLETED
High Resolution Retinal Imaging
NCT01866371 RECRUITING
Novel Glaucoma Diagnostics
NCT00286637 RECRUITING