Correlation Between Aqueous Protein Level and Clinical Grading of Flare and Flaremetry.

NCT ID: NCT01905579

Last Updated: 2014-09-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2013-08-31

Brief Summary

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The purpose of this study is to compare flaremetry readings with the protein content of the aqueous humor and the clinical grading of flare.

Detailed Description

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A total of 20 patients will be included. 10 patients with uveitis and 10 control patients scheduled for phacoemulsification. Each patient will undego complete ophthalmic examination and clinical biomicroscopic grading of the anterior chamber flare applying the SUN working group grading system. Aqueous specimens will be obtained by anterior chamber paracentesis for protein analysis. Each Patient will undego paracentesis and 0.2 ml of aqueous will be obtained. The aqueous sample will be stored at -70°C until the time of analysis for protein content. Objective assessment of flare will be done.

Conditions

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Uveitis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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patients with uveitis

Paracentesis of the anterior chamber in Paients with uveitis undergoing cataract surgery

Group Type EXPERIMENTAL

Paracentesis of the anterior chamber

Intervention Type PROCEDURE

Aqueous humor parenthesis for quantitative protein analysis in patients with and without uveitis.

patients without uveitis

Paracentesis of the anterior chamber in patients without uveitis undergoing routine cataract surgery

Group Type EXPERIMENTAL

Paracentesis of the anterior chamber

Intervention Type PROCEDURE

Aqueous humor parenthesis for quantitative protein analysis in patients with and without uveitis.

Interventions

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Paracentesis of the anterior chamber

Aqueous humor parenthesis for quantitative protein analysis in patients with and without uveitis.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 10 patients with uveitis with cataract
* 10 patients without uveitis with cataract
* Inactive inflammation for at least 3 months

Exclusion Criteria

* Infectious uveitis
* endophthalmitis
* cases with corneal scar
Minimum Eligible Age

10 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Eye Center and The Eye Foundation for Research in Ophthalmology

OTHER

Sponsor Role lead

Responsible Party

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Samir S. Shoughy, MD, FRCS (Glasg.)

Ophthalmologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Samir S Shoughy

Role: PRINCIPAL_INVESTIGATOR

THE EYE CENTER

Locations

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The Eye Center

Riyadh, , Saudi Arabia

Site Status

Countries

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Saudi Arabia

References

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Shoughy SS, Elkum N, Tabbara KF. Aqueous protein level and flare grading. Acta Ophthalmol. 2015 Mar;93(2):e173-4. doi: 10.1111/aos.12522. Epub 2014 Aug 31. No abstract available.

Reference Type DERIVED
PMID: 25175512 (View on PubMed)

Other Identifiers

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TEC 2012-003

Identifier Type: OTHER

Identifier Source: secondary_id

TEC 123

Identifier Type: -

Identifier Source: org_study_id

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