Microbiome and Colorectal Cancer Recurrence

NCT ID: NCT07057076

Last Updated: 2025-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

51 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-01-01

Study Completion Date

2024-06-01

Brief Summary

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Anastomotic leak is associated with higher rates of tumor recurrence after colorectal cancer surgery. However, the mechanisms responsible remain unknown. The aim of this study is to identify associations between the peritoneal microbiome and recurrence in colorectal cancer patients with postoperative anastomotic leak. This is a single-center retrospective study of patients undergoing colorectal cancer surgery complicated with anastomotic leak between 2004 and 2012. Samples of peritoneal fluid were collected either through percutaneous drainage or reoperation, and microbiome was analyzed using whole genome shotgun. Oncological outcomes are registered. Associations between peritoneal microbiome and tumor recurrence are investigated.

Detailed Description

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Conditions

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Colorectal Cancer Recurrent

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Colorectal cancer patients

Colorectal cancer patients operated on for cure and complicated by anastomotic leak

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Colorectal cancer patients operated on for cure and complicated with anastomotic leak.

Exclusion Criteria

* Non-curative resection.
* Urgent surgery.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital del Mar

OTHER

Sponsor Role lead

Responsible Party

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Blanca Montcusí Ventura

Colorectal Surgeon

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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PI19/00643

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

SGR 00024

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2020/9513/I

Identifier Type: -

Identifier Source: org_study_id

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