Integrative Omics Analysis for Colorectal Cancer and Metastasis

NCT ID: NCT05482529

Last Updated: 2022-08-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-08-01

Study Completion Date

2025-12-31

Brief Summary

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The pathogenesis of Colorectal cancer (CRC) metastasis remains unclear.We collect clinical data from our center and use Integrative omics to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis.

Detailed Description

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Colorectal cancer (CRC), one of the most common malignant cancer around the world, CRC patients with distant metastasis. However, the pathogenesis of metastasis remains unclear. Integrative omics have begun to enable personalized medicine at an extraordinarily detailed molecular level. All patients with colorectal cancer and metastasis in our center who meet the inclusion criteria and exclusion criteria will be enrolled. The specimen collected by surgery and clinical data will be collected . We use Integrative omics such as RNA-sequencing,ATAC-seq(Assay for Transposase-Accessible Chromatin using sequencing), CUT\&Tag( Cleavage Under Targets and Tagmentation)to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis. This study will contribute to understanding the molecular mechanism of CRC metastasis in depth and contribute to the discovery of new appropriate molecular diagnostic and therapeutic targets, and more accurately prognose long term outcome in patients with CRC.

Conditions

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Colorectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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colorectal cancer with metastasis

colorectal cancer patients with at least one distant metastasis(liver, lung)

Integrative omics

Intervention Type OTHER

Integrative omics such as RNA-sequencing,ATAC-seq(Assay for Transposase-Accessible Chromatin using sequencing), CUT\&Tag( Cleavage Under Targets and Tagmentation)to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis.

Interventions

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Integrative omics

Integrative omics such as RNA-sequencing,ATAC-seq(Assay for Transposase-Accessible Chromatin using sequencing), CUT\&Tag( Cleavage Under Targets and Tagmentation)to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* colorectal adenocarcinoma by biopsy。
* at least 1 metastasis lesion comfirmed by at least 1 kind of imaging examination (CT, MRI and PET-CT )

Exclusion Criteria

* recent diagnosis with other malignancies
* can not tolerate the surgery
* history of serious mental illness
* pregnancy or lactating women
* the researchers believe the patients should not enrolled in
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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fan li

OTHER

Sponsor Role lead

Responsible Party

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fan li

Prof.

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Daping hospital

Chongqing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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fan li, MD

Role: CONTACT

86 023 68757958

Facility Contacts

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fan Li, PhD

Role: primary

Other Identifiers

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IOACCM

Identifier Type: -

Identifier Source: org_study_id

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